SPDL1 and CA8

Data Source:
BioGRID (two hybrid, two hybrid)

		SPDL1	CA8
Description		spindle apparatus coiled-coil protein 1	carbonic anhydrase 8
Image		No pdb structure
GO Annotations	Cellular Component	Spindle Pole Condensed Chromosome Outer Kinetochore Nucleus Microtubule Organizing Center Cytosol	Cytoplasm
	Molecular Function	Protein Binding Enzyme Binding Kinetochore Binding	Carbonate Dehydratase Activity Protein Binding Zinc Ion Binding Hydro-lyase Activity
	Biological Process	Establishment Of Mitotic Spindle Orientation Mitotic Metaphase Plate Congression Mitotic Spindle Assembly Checkpoint Cell Migration Protein Localization To Kinetochore Cell Division	One-carbon Metabolic Process Phosphatidylinositol-mediated Signaling
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs			Zonisamide
Diseases
GWAS			Adult body size ( 32376654) Blood protein levels ( 30072576) Cardiac hypertrophy ( 21348951) Free thyroxine concentration ( 30367059) Height ( 31562340) Hemoglobin ( 32888494) Myopia ( 27182965) Obesity-related traits ( 23251661) Parkinson's disease ( 27182965) Red blood cell count ( 32888494) Refractive error ( 32231278) Response to amphetamines ( 22952603) Schizophrenia ( 28991256 25056061 29483656 30285260) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		10 interacting genes: CA8 CEP126 DNAAF4 GPS2 ITSN1 PPP1R18 RTP5 TRAF4 USP15 USP45	14 interacting genes: CRX GGA2 HSD17B14 INTS7 ITPR1 KLHL8 LMNB2 LNX1 LRCH4 MAGED1 RAB34 SPDL1 STAT3 TBX3
Entrez ID		54908	767
HPRD ID		08623	00266
Ensembl ID		ENSG00000040275	ENSG00000178538
Uniprot IDs		Q96EA4	P35219
PDB IDs			2W2J
Enriched GO Terms of Interacting Partners?
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