CA8 and KLHL8

Data Source:
BioGRID (two hybrid)

		CA8	KLHL8
Description		carbonic anhydrase 8	kelch like family member 8
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Nucleoplasm Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Carbonate Dehydratase Activity Protein Binding Zinc Ion Binding Hydro-lyase Activity
	Biological Process	One-carbon Metabolic Process Phosphatidylinositol-mediated Signaling	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination
Pathways
Drugs		Zonisamide
Diseases
GWAS		Adult body size ( 32376654) Blood protein levels ( 30072576) Cardiac hypertrophy ( 21348951) Free thyroxine concentration ( 30367059) Height ( 31562340) Hemoglobin ( 32888494) Myopia ( 27182965) Obesity-related traits ( 23251661) Parkinson's disease ( 27182965) Red blood cell count ( 32888494) Refractive error ( 32231278) Response to amphetamines ( 22952603) Schizophrenia ( 28991256 25056061 29483656 30285260) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Alanine transaminase levels ( 29403010) Aspartate aminotransferase levels ( 29403010) Bulimia nervosa ( 23568457) Eyebrow thickness ( 26926045) HDL cholesterol levels ( 28334899) Rosacea symptom severity ( 29771307) Total cholesterol levels ( 30275531) Triglyceride levels ( 28334899 29403010) Triglycerides ( 24097068 25961943 20686565)
Interacting Genes		14 interacting genes: CRX GGA2 HSD17B14 INTS7 ITPR1 KLHL8 LMNB2 LNX1 LRCH4 MAGED1 RAB34 SPDL1 STAT3 TBX3	13 interacting genes: ARMC9 ATXN1 CA8 COIL MAPK9 PNMT PPM1F RAPSN RLBP1 SULT2B1 TEX101 TP53I13 USP7
Entrez ID		767	57563
HPRD ID		00266	13928
Ensembl ID		ENSG00000178538	ENSG00000145332
Uniprot IDs		P35219	B3KY78 Q68DU9 Q7Z330 Q9P2G9
PDB IDs		2W2J
Enriched GO Terms of Interacting Partners?
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