SPDL1 and USP45

Data Source:
BioGRID (enzymatic study, affinity chromatography technology)

		SPDL1	USP45
Description		spindle apparatus coiled-coil protein 1	ubiquitin specific peptidase 45
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Spindle Pole Condensed Chromosome Outer Kinetochore Nucleus Microtubule Organizing Center Cytosol	Photoreceptor Inner Segment Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Protein Binding Enzyme Binding Kinetochore Binding	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity Zinc Ion Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Mitotic Metaphase Plate Congression Mitotic Spindle Assembly Checkpoint Cell Migration Protein Localization To Kinetochore Cell Division	Neural Retina Development DNA Repair Ubiquitin-dependent Protein Catabolic Process Cell Migration Protein Deubiquitination Protein Phosphopantetheinylation Photoreceptor Cell Maintenance Global Genome Nucleotide-excision Repair
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Formation of Incision Complex in GG-NER
Drugs
Diseases
GWAS			Erectile dysfunction ( 30297428) Pursuit maintenance gain ( 29064472)
Interacting Genes		10 interacting genes: CA8 CEP126 DNAAF4 GPS2 ITSN1 PPP1R18 RTP5 TRAF4 USP15 USP45	7 interacting genes: BMPR1B ERCC1 SMAD1 SMURF1 SPDL1 TGFBR1 UBC
Entrez ID		54908	85015
HPRD ID		08623	11667
Ensembl ID		ENSG00000040275	ENSG00000123552
Uniprot IDs		Q96EA4	D6RBV3 Q70EL2
PDB IDs
Enriched GO Terms of Interacting Partners?
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