SPDL1 and USP15

Data Source:
BioGRID (two hybrid)

		SPDL1	USP15
Description		spindle apparatus coiled-coil protein 1	ubiquitin specific peptidase 15
Image		No pdb structure
GO Annotations	Cellular Component	Spindle Pole Condensed Chromosome Outer Kinetochore Nucleus Microtubule Organizing Center Cytosol	Nucleus Cytoplasm Mitochondrion Cytosol Plasma Membrane
	Molecular Function	Protein Binding Enzyme Binding Kinetochore Binding	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Identical Protein Binding SMAD Binding Ubiquitin Modification-dependent Histone Binding Lys48-specific Deubiquitinase Activity
	Biological Process	Establishment Of Mitotic Spindle Orientation Mitotic Metaphase Plate Congression Mitotic Spindle Assembly Checkpoint Cell Migration Protein Localization To Kinetochore Cell Division	Ubiquitin-dependent Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Viral Process Protein Deubiquitination Protein Phosphopantetheinylation BMP Signaling Pathway Monoubiquitinated Protein Deubiquitination Histone H2B Conserved C-terminal Lysine Deubiquitination Pathway-restricted SMAD Protein Phosphorylation Protein K48-linked Deubiquitination Positive Regulation Of RIG-I Signaling Pathway
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Downregulation of TGF-beta receptor signaling UCH proteinases Ub-specific processing proteases
Drugs
Diseases
GWAS			Alopecia areata ( 25608926) Metabolite levels ( 23823483) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Pulmonary function decline ( 22424883) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271)
Interacting Genes		10 interacting genes: CA8 CEP126 DNAAF4 GPS2 ITSN1 PPP1R18 RTP5 TRAF4 USP15 USP45	55 interacting genes: BAP1 BMI1 BMPR1A BRAP CARD9 CCDC57 DDX58 FHL1 GEMIN4 GOLGA2 GOLGA6A H2BC21 IL1R2 JOSD1 KEAP1 MAD1L1 MDC1 MDM2 OTUB1 PHF7 PIBF1 PLA2G2A PRPF31 RBCK1 RNF126 RNF144B SENP3 SENP8 SMURF2 SPDL1 STAM STK33 SYVN1 TEX11 TRAF6 TRIM17 TRIM21 TRIM25 TRIM46 TRIM5 TRIM54 TRIM63 TRIM74 UBE2S UCHL1 UCHL3 USP14 USP2 USP20 USP21 USP28 USP33 USP51 USP8 YOD1
Entrez ID		54908	9958
HPRD ID		08623	05293
Ensembl ID		ENSG00000040275	ENSG00000135655
Uniprot IDs		Q96EA4	Q9Y4E8
PDB IDs			1W6V 3LMN 3PPA 3PV1 3T9L 4A3O 4A3P 5JJW 6CPM 6CRN 6DJ9 6GH9 6GHA 6ML1
Enriched GO Terms of Interacting Partners?
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