BCAS3 and CDC23

Data Source:
BioGRID (two hybrid)

		BCAS3	CDC23
Description		BCAS3 microtubule associated cell migration factor	cell division cycle 23
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytoplasmic Microtubule Cell Leading Edge Transcriptionally Active Chromatin Intermediate Filament Cytoskeleton	Nucleoplasm Anaphase-promoting Complex Cytoplasm Cytosol
	Molecular Function	Chromatin Binding Protein Binding Transcription Factor Binding Acetyltransferase Activator Activity Histone Acetyltransferase Binding Nuclear Hormone Receptor Binding Histone Binding Beta-tubulin Binding	Ubiquitin-protein Transferase Activity Protein Binding
	Biological Process	Angiogenesis Golgi Organization Positive Regulation Of Endothelial Cell Migration Microtubule Organizing Center Organization Negative Regulation Of GTPase Activity Tube Formation Response To Starvation Positive Regulation Of Catalytic Activity Positive Regulation Of GTPase Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Filopodium Assembly Negative Regulation Of Focal Adhesion Assembly Cellular Response To Estrogen Stimulus Positive Regulation Of Intracellular Protein Transport Activation Of GTPase Activity Regulation Of Establishment Of Cell Polarity Positive Regulation Of Actin Cytoskeleton Reorganization	Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Mitotic Metaphase Plate Congression Metaphase/anaphase Transition Of Mitotic Cell Cycle Regulation Of Exit From Mitosis Protein Ubiquitination Regulation Of Mitotic Metaphase/anaphase Transition Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Protein K11-linked Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition
Pathways			Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Airway responsiveness in chronic obstructive pulmonary disease ( 25514360) Alzheimer's disease (cognitive decline) ( 23535033) Blood urea nitrogen levels ( 31152163 29403010) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Calcium levels ( 29403010) Chronic kidney disease ( 31152163 20383146) Coronary artery disease ( 32469254 29212778 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 31152163 31451708 29779033 30604766) Estimated glomerular filtration rate in diabetes ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) FEV1 ( 30804560) Glomerular filtration rate ( 27588450 29403010) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Gout ( 32238385 25967671) Gout (combined type) ( 32238385) Heel bone mineral density ( 30598549 28869591) Height ( 18391951) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) Immune reponse to smallpox (secreted IL-2) ( 22610502) Intraocular pressure ( 29617998 29785010 31959993 30054594) Lung function (FEV1/FVC) ( 30804560) Macular thickness ( 30535121) Medial orbital frontal cortex volume ( 31530798) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (diuretics) ( 31015401) Metabolite levels (small molecules and protein measures) ( 27005778) Myocardial infarction ( 26343387) Obesity-related traits ( 23251661) Optic cup area ( 25631615 31798171 28073927) Optic disc size ( 31809533) Platelet count ( 32888494) Plateletcrit ( 32888494) Pulse pressure ( 30578418) Red blood cell count ( 32888494 27863252) Red cell distribution width ( 32888494) Refractive error ( 32231278) Renal function-related traits (BUN) ( 22797727) Renal function-related traits (eGRFcrea) ( 22797727) Renal function-related traits (sCR) ( 22797727) Serum creatinine levels ( 29779033) Serum uric acid levels ( 30993211 29403010 32514006) Systolic blood pressure ( 30224653 30578418) Thyroid stimulating hormone levels ( 30367059 32769997) Urate levels ( 31985003 31578528 23263486) Urolithiasis ( 30975718) Vertical cup-disc ratio ( 20548946) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Autism spectrum disorder or schizophrenia ( 28540026) Resting heart rate ( 27798624)
Interacting Genes		21 interacting genes: ATM BAG4 CCND1 CDC23 CTBP1 CTBP2 FBXW7 H3C1 KRAS MTDH PALB2 PELP1 PHB PLEKHF2 PTPN1 SMAD4 STK11 TGFB1 TSG101 XRCC3 ZDHHC17	81 interacting genes: ANAPC10 ANAPC13 ANKRD11 APOL1 ATRIP BCAS3 BEGAIN BHLHB9 BYSL C21orf91 CBY2 CCDC125 CCDC24 CCDC33 CDC16 CDT1 CEP44 CERCAM COIL CRACR2A CRTC2 CTBP1 CYB5R2 DCLK1 DEPDC1B DISC1 DLX6-AS1 EIF5A2 FAM9B FBXO5 FOXN1 GORASP2 GTPBP8 HEMK1 IHO1 INCA1 INO80E INPP5J KCTD6 KDM1A KRT36 LHX3 LZTS1 LZTS2 MAGED1 MAPK3 NAB2 NRBF2 NUP54 OPTN PFKFB4 PIH1D2 PNMA5 POU6F2 PROSER3 PRPF31 PRR22 RAC1 RAD54B RBM15B RBP3 RBPMS RSL24D1 RUNX1T1 SIAH1 SLC52A2 SMARCB1 SMUG1 SORBS3 SOX5 SPAG8 SSX2IP STX2 SUV39H1 TEPSIN TNIP1 TRIM27 TSC22D4 UBE2S USP54 ZMAT1
Entrez ID		54828	8697
HPRD ID		06313	07221
Ensembl ID		ENSG00000141376	ENSG00000094880
Uniprot IDs		K7ESE9 Q05D99 Q9H6U6	Q9UJX2
PDB IDs			4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5
Enriched GO Terms of Interacting Partners?
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