BCAS3 and PHB

Data Source:
BioGRID (two hybrid)

		BCAS3	PHB
Description		BCAS3 microtubule associated cell migration factor	prohibitin
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytoplasmic Microtubule Cell Leading Edge Transcriptionally Active Chromatin Intermediate Filament Cytoskeleton	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Early Endosome Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Postsynaptic Density Membrane Mitochondrial Crista Extrinsic Component Of Mitochondrial Outer Membrane Mitochondrial Prohibitin Complex Extracellular Exosome Extrinsic Component Of Presynaptic Active Zone Membrane Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Chromatin Binding Protein Binding Transcription Factor Binding Acetyltransferase Activator Activity Histone Acetyltransferase Binding Nuclear Hormone Receptor Binding Histone Binding Beta-tubulin Binding	Complement Component C3a Binding Complement Component C3b Binding Transcription Corepressor Activity Protein Binding Protein C-terminus Binding Enzyme Binding Proteinase Activated Receptor Binding Histone Deacetylase Binding Protein Heterodimerization Activity
	Biological Process	Angiogenesis Golgi Organization Positive Regulation Of Endothelial Cell Migration Microtubule Organizing Center Organization Negative Regulation Of GTPase Activity Tube Formation Response To Starvation Positive Regulation Of Catalytic Activity Positive Regulation Of GTPase Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Filopodium Assembly Negative Regulation Of Focal Adhesion Assembly Cellular Response To Estrogen Stimulus Positive Regulation Of Intracellular Protein Transport Activation Of GTPase Activity Regulation Of Establishment Of Cell Polarity Positive Regulation Of Actin Cytoskeleton Reorganization	Negative Regulation Of Transcription By RNA Polymerase II Ovarian Follicle Development Ovarian Follicle Atresia Osteoblast Differentiation Immunoglobulin Production Regulation Of Transcription, DNA-templated Mitochondrial Calcium Ion Transmembrane Transport Mitochondrion Organization Signal Transduction Activation Of Phospholipase C Activity Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Cell Death Negative Regulation Of Transcription By Competitive Promoter Binding Histone Deacetylation CD40 Signaling Pathway Negative Regulation Of Cell Growth Animal Organ Regeneration Interleukin-17 Production Response To Immobilization Stress RIG-I Signaling Pathway B Cell Activation Negative Regulation Of Protein Catabolic Process Response To Drug Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Response To Peptide Hormone Modulation By Host Of Viral RNA Genome Replication Response To Ethanol Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Complement Activation Viral Entry Into Host Cell Positive Regulation Of Smooth Muscle Cell Proliferation Protein Stabilization Progesterone Receptor Signaling Pathway Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interleukin-6 DNA Biosynthetic Process T-helper 17 Type Immune Response Antiviral Innate Immune Response Positive Regulation Of NIK/NF-kappaB Signaling Activation Of Protein Kinase C Activity Negative Regulation Of Glucocorticoid Receptor Signaling Pathway
Pathways			RAF activation Signaling by moderate kinase activity BRAF mutants Paradoxical activation of RAF signaling by kinase inactive BRAF Processing of SMDT1 Signaling downstream of RAS mutants
Drugs			Rocaglamide Didesmethylrocaglamide
Diseases
GWAS		Airway responsiveness in chronic obstructive pulmonary disease ( 25514360) Alzheimer's disease (cognitive decline) ( 23535033) Blood urea nitrogen levels ( 31152163 29403010) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Calcium levels ( 29403010) Chronic kidney disease ( 31152163 20383146) Coronary artery disease ( 32469254 29212778 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 31152163 31451708 29779033 30604766) Estimated glomerular filtration rate in diabetes ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) FEV1 ( 30804560) Glomerular filtration rate ( 27588450 29403010) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Gout ( 32238385 25967671) Gout (combined type) ( 32238385) Heel bone mineral density ( 30598549 28869591) Height ( 18391951) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) Immune reponse to smallpox (secreted IL-2) ( 22610502) Intraocular pressure ( 29617998 29785010 31959993 30054594) Lung function (FEV1/FVC) ( 30804560) Macular thickness ( 30535121) Medial orbital frontal cortex volume ( 31530798) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (diuretics) ( 31015401) Metabolite levels (small molecules and protein measures) ( 27005778) Myocardial infarction ( 26343387) Obesity-related traits ( 23251661) Optic cup area ( 25631615 31798171 28073927) Optic disc size ( 31809533) Platelet count ( 32888494) Plateletcrit ( 32888494) Pulse pressure ( 30578418) Red blood cell count ( 32888494 27863252) Red cell distribution width ( 32888494) Refractive error ( 32231278) Renal function-related traits (BUN) ( 22797727) Renal function-related traits (eGRFcrea) ( 22797727) Renal function-related traits (sCR) ( 22797727) Serum creatinine levels ( 29779033) Serum uric acid levels ( 30993211 29403010 32514006) Systolic blood pressure ( 30224653 30578418) Thyroid stimulating hormone levels ( 30367059 32769997) Urate levels ( 31985003 31578528 23263486) Urolithiasis ( 30975718) Vertical cup-disc ratio ( 20548946) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Asthma ( 31959851 30929738 32296059 29273806) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 31036433 30929738) Cancer ( 29299148) Coronary artery disease ( 29212778 33020668) Diastolic blood pressure ( 19430483 27841878) Lower body strength ( 27325353) Metabolite levels ( 23823483) Prostate cancer ( 23535732) Refractive error ( 32231278) Restricted and repetitive behaviours in autism spectrum disorder ( 28533516) Systolic blood pressure ( 27841878 30578418)
Interacting Genes		21 interacting genes: ATM BAG4 CCND1 CDC23 CTBP1 CTBP2 FBXW7 H3C1 KRAS MTDH PALB2 PELP1 PHB PLEKHF2 PTPN1 SMAD4 STK11 TGFB1 TSG101 XRCC3 ZDHHC17	25 interacting genes: ANXA2 BCAS3 CASC3 CCL5 COX6C E2F1 ESR1 HDAC1 LONRF3 MAP3K10 MCM2 NCOR1 PTEN RAF1 RB1 RBL1 RBL2 SEC22A SIN3A SMARCA2 SMARCA4 ST14 SUMO4 TP53 XPO1
Entrez ID		54828	5245
HPRD ID		06313	01454
Ensembl ID		ENSG00000141376	ENSG00000167085
Uniprot IDs		K7ESE9 Q05D99 Q9H6U6	A8K401 P35232 Q53FV0
PDB IDs			1LU7
Enriched GO Terms of Interacting Partners?
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