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SMAD7 and SIRT1
Data Source:
BioGRID
(pull down)
SMAD7
SIRT1
Description
SMAD family member 7
sirtuin 1
Image
GO Annotations
Cellular Component
Chromatin
Fibrillar Center
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Cytosol
Plasma Membrane
Adherens Junction
Catenin Complex
Protein-containing Complex
Heteromeric SMAD Protein Complex
Chromatin
Euchromatin
Heterochromatin
Fibrillar Center
Nucleus
Nuclear Envelope
Nuclear Inner Membrane
Nucleoplasm
Chromatin Silencing Complex
Nucleolus
Cytoplasm
Mitochondrion
Cytosol
PML Body
RDNA Heterochromatin
ESC/E(Z) Complex
Molecular Function
DNA Binding
Protein Binding
Collagen Binding
Beta-catenin Binding
Ubiquitin Protein Ligase Binding
Type I Transforming Growth Factor Beta Receptor Binding
Metal Ion Binding
Activin Binding
I-SMAD Binding
Transcription Regulator Inhibitor Activity
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
P53 Binding
Transcription Coactivator Activity
Transcription Corepressor Activity
NAD+ ADP-ribosyltransferase Activity
Histone Deacetylase Activity
Protein Binding
Protein C-terminus Binding
Transcription Factor Binding
NAD-dependent Histone Deacetylase Activity
Deacetylase Activity
Enzyme Binding
Protein Deacetylase Activity
NAD-dependent Protein Deacetylase Activity
Nuclear Hormone Receptor Binding
Histone Binding
Identical Protein Binding
HLH Domain Binding
BHLH Transcription Factor Binding
Metal Ion Binding
NAD-dependent Histone Deacetylase Activity (H3-K9 Specific)
Mitogen-activated Protein Kinase Binding
NAD+ Binding
Protein-propionyllysine Depropionylase Activity
Keratin Filament Binding
Promoter-specific Chromatin Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Ureteric Bud Development
Negative Regulation Of T Cell Cytokine Production
Regulation Of Transcription By RNA Polymerase II
Transforming Growth Factor Beta Receptor Signaling Pathway
Anatomical Structure Morphogenesis
Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Peptidyl-threonine Phosphorylation
Negative Regulation Of Transcription By Competitive Promoter Binding
Protein Deubiquitination
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of Cell-cell Adhesion
Cell Differentiation
Negative Regulation Of Ossification
Negative Regulation Of Cell Migration
BMP Signaling Pathway
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of BMP Signaling Pathway
Negative Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Activin Receptor Signaling Pathway
Negative Regulation Of Peptidyl-serine Phosphorylation
Adherens Junction Assembly
Response To Laminar Fluid Shear Stress
Cellular Protein-containing Complex Localization
Negative Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of Transcription By RNA Polymerase II
Artery Morphogenesis
Protein Stabilization
Negative Regulation Of Ubiquitin-protein Transferase Activity
Ventricular Cardiac Muscle Tissue Morphogenesis
Regulation Of Cardiac Muscle Contraction
Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization
Pathway-restricted SMAD Protein Phosphorylation
Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation
SMAD Protein Signal Transduction
Ventricular Septum Morphogenesis
Cellular Response To Transforming Growth Factor Beta Stimulus
Negative Regulation Of Chondrocyte Proliferation
Positive Regulation Of Chondrocyte Hypertrophy
Cellular Response To Leukemia Inhibitory Factor
Negative Regulation Of T-helper 17 Type Immune Response
Negative Regulation Of T-helper 17 Cell Differentiation
Single Strand Break Repair
Negative Regulation Of Transcription By RNA Polymerase II
RDNA Heterochromatin Assembly
Pyrimidine Dimer Repair By Nucleotide-excision Repair
DNA Synthesis Involved In DNA Repair
Angiogenesis
Ovulation From Ovarian Follicle
Cellular Glucose Homeostasis
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Endothelial Cell Proliferation
Positive Regulation Of Adaptive Immune Response
Chromatin Organization
DNA Methylation-dependent Heterochromatin Assembly
Protein ADP-ribosylation
Protein Deacetylation
Triglyceride Mobilization
Cellular Response To DNA Damage Stimulus
Response To Oxidative Stress
Transforming Growth Factor Beta Receptor Signaling Pathway
Spermatogenesis
Regulation Of Mitotic Cell Cycle
Muscle Organ Development
Cell Aging
Positive Regulation Of Cell Population Proliferation
Cellular Response To Starvation
Negative Regulation Of Gene Expression
Regulation Of Centrosome Duplication
Positive Regulation Of Cholesterol Efflux
Regulation Of Lipid Storage
Regulation Of Glucose Metabolic Process
Macrophage Cytokine Production
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Viral Process
Positive Regulation Of Macroautophagy
Protein Ubiquitination
Histone Deacetylation
Peptidyl-lysine Acetylation
Macrophage Differentiation
Negative Regulation Of Cell Growth
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Prostaglandin Biosynthetic Process
Heterochromatin Assembly
Protein Destabilization
Negative Regulation Of TOR Signaling
Regulation Of Endodeoxyribonuclease Activity
Negative Regulation Of NF-kappaB Transcription Factor Activity
Response To Insulin
Circadian Regulation Of Gene Expression
Leptin-mediated Signaling Pathway
Regulation Of Smooth Muscle Cell Apoptotic Process
Peptidyl-lysine Deacetylation
Cellular Triglyceride Homeostasis
Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway
Regulation Of Cell Population Proliferation
Negative Regulation Of Phosphorylation
Response To Hydrogen Peroxide
Behavioral Response To Starvation
Cholesterol Homeostasis
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Negative Regulation Of DNA-binding Transcription Factor Activity
Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Response To Leptin
Positive Regulation Of MHC Class II Biosynthetic Process
Negative Regulation Of Fat Cell Differentiation
Positive Regulation Of Gluconeogenesis
Positive Regulation Of DNA Repair
Positive Regulation Of Angiogenesis
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Insulin Receptor Signaling Pathway
White Fat Cell Differentiation
Negative Regulation Of Helicase Activity
Positive Regulation Of Smooth Muscle Cell Differentiation
Positive Regulation Of Histone H3-K9 Methylation
Negative Regulation Of Protein Kinase B Signaling
Fatty Acid Homeostasis
Negative Regulation Of Androgen Receptor Signaling Pathway
Histone H3-K9 Modification
Cellular Response To Hydrogen Peroxide
Heterochromatin Maintenance
Regulation Of Bile Acid Biosynthetic Process
UV-damage Excision Repair
Histone H3 Deacetylation
Cellular Response To Tumor Necrosis Factor
Negative Regulation Of Histone H3-K14 Acetylation
Cellular Response To Hypoxia
Cellular Response To Ionizing Radiation
Regulation Of Protein Serine/threonine Kinase Activity
Regulation Of Brown Fat Cell Differentiation
Stress-induced Premature Senescence
Protein Depropionylation
Regulation Of Cellular Response To Heat
Negative Regulation Of Histone H3-K9 Trimethylation
Negative Regulation Of Neuron Death
Negative Regulation Of Protein Acetylation
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Adipose Tissue Development
Histone H3-K9 Deacetylation
Cellular Response To Leukemia Inhibitory Factor
Positive Regulation Of Macrophage Apoptotic Process
Negative Regulation Of CAMP-dependent Protein Kinase Activity
Positive Regulation Of CAMP-dependent Protein Kinase Activity
Negative Regulation Of Histone H4-K16 Acetylation
Negative Regulation Of Cellular Response To Testosterone Stimulus
Negative Regulation Of Peptidyl-lysine Acetylation
Negative Regulation Of Cellular Senescence
Positive Regulation Of Cellular Senescence
Pathways
Signaling by BMP
Downregulation of TGF-beta receptor signaling
Downregulation of TGF-beta receptor signaling
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
UCH proteinases
Ub-specific processing proteases
Regulation of HSF1-mediated heat shock response
Circadian Clock
SIRT1 negatively regulates rRNA expression
SIRT1 negatively regulates rRNA expression
Regulation of FOXO transcriptional activity by acetylation
Regulation of FOXO transcriptional activity by acetylation
Drugs
Resveratrol
Selisistat
Cambinol
Diseases
GWAS
Asthma (
32296059
)
Atrial fibrillation (
30061737
29892015
)
Colorectal cancer (
25990418
18372901
18372905
30529582
21761138
17934461
26151821
29228715
30104761
24836286
29471430
24448986
31826910
23266556
)
Colorectal cancer or advanced adenoma (
30510241
)
Coronary artery disease (
33020668
)
Creatinine levels (
29403010
)
Dental caries (
23064961
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Estimated glomerular filtration rate (
31152163
31015462
30604766
)
Glomerular filtration rate (
29403010
)
Heel bone mineral density (
30598549
)
Hematocrit (
32888494
27863252
)
Hemoglobin (
32888494
)
Hemoglobin concentration (
27863252
)
Hemoglobin levels (
32327693
)
Inflammatory bowel disease (
23128233
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Parental longevity (at least one long-lived parent) (
27816938
)
Red blood cell count (
32888494
27863252
)
Atrial fibrillation (
30061737
)
Chronotype (
30696823
)
Diverticular disease (
30177863
)
Molybdenum levels (
26025379
)
Pulse pressure (
30224653
)
Interacting Genes
59 interacting genes:
ACVR1B
AKT1
ASH1L
AXIN1
AXIN2
BMPR1B
CBL
CTNNB1
CXXC5
DVL1
EP300
ERBIN
HAT1
HEYL
KDM2A
MAP2K3
MAP2K6
MAP3K7
MAPK14
MBD1
MRTFB
MYOD1
NEDD4L
OTUD1
PARD3
PIAS1
PIAS4
RLIM
RNF111
SASH3
SETD7
SIRT1
SMAD2
SMAD3
SMAD4
SMAD6
SMURF1
SMURF2
SOX13
SOX5
SOX7
STAMBP
STAMBPL1
STRAP
TAB1
TGFB1I1
TGFBR1
TGFBR2
TTF1
TTF2
UBE2L3
UCHL5
WWP2
XRCC6
YAP1
ZBTB11
ZBTB44
ZEB1
ZNF107
63 interacting genes:
AFP
AKT1
AR
ARNTL
BCL11A
BHLHE41
BRIP1
CDK6
CENATAC
CHFR
CLOCK
CSNK2B
CTTN
E2F1
EP300
ESRRA
EZH2
FOS
FOXM1
FOXO1
FOXO3
GAPDH
H1-5
H3C1
HES1
HEY2
HIC1
HIPK2
HNF4A
HOXB9
MAPK8
MAPT
MPHOSPH8
MYCN
NBN
NDN
NMNAT1
NR1H2
NR1H3
NR1H4
PARP1
PML
PPARA
PPARG
PPARGC1A
PRMT1
PSME3
RARA
RELA
RICTOR
RRP8
SATB1
SETD7
SMAD7
SNW1
STK11
STK4
SUMO2
TP53
TP73
TRIM28
UBE2I
VDR
Entrez ID
4092
23411
HPRD ID
04241
08381
Ensembl ID
ENSG00000101665
ENSG00000096717
Uniprot IDs
B3KYA8
O15105
A0A024QZQ1
A8K128
B0QZ35
E9PC49
Q96EB6
PDB IDs
2DJY
2KXQ
2LTV
2LTW
2LTX
2LTY
2LTZ
4I5I
4IF6
4IG9
4KXQ
4ZZH
4ZZI
4ZZJ
5BTR
Enriched GO Terms of Interacting Partners
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