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SMAD7 and ZBTB11
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
SMAD7
ZBTB11
Description
SMAD family member 7
zinc finger and BTB domain containing 11
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Fibrillar Center
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Cytosol
Plasma Membrane
Adherens Junction
Catenin Complex
Protein-containing Complex
Heteromeric SMAD Protein Complex
Nucleoplasm
Nucleolus
Molecular Function
DNA Binding
Protein Binding
Collagen Binding
Beta-catenin Binding
Ubiquitin Protein Ligase Binding
Type I Transforming Growth Factor Beta Receptor Binding
Metal Ion Binding
Activin Binding
I-SMAD Binding
Transcription Regulator Inhibitor Activity
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Molecular_function
Metal Ion Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Ureteric Bud Development
Negative Regulation Of T Cell Cytokine Production
Regulation Of Transcription By RNA Polymerase II
Transforming Growth Factor Beta Receptor Signaling Pathway
Anatomical Structure Morphogenesis
Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Peptidyl-threonine Phosphorylation
Negative Regulation Of Transcription By Competitive Promoter Binding
Protein Deubiquitination
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of Cell-cell Adhesion
Cell Differentiation
Negative Regulation Of Ossification
Negative Regulation Of Cell Migration
BMP Signaling Pathway
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of BMP Signaling Pathway
Negative Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Activin Receptor Signaling Pathway
Negative Regulation Of Peptidyl-serine Phosphorylation
Adherens Junction Assembly
Response To Laminar Fluid Shear Stress
Cellular Protein-containing Complex Localization
Negative Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of Transcription By RNA Polymerase II
Artery Morphogenesis
Protein Stabilization
Negative Regulation Of Ubiquitin-protein Transferase Activity
Ventricular Cardiac Muscle Tissue Morphogenesis
Regulation Of Cardiac Muscle Contraction
Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization
Pathway-restricted SMAD Protein Phosphorylation
Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation
SMAD Protein Signal Transduction
Ventricular Septum Morphogenesis
Cellular Response To Transforming Growth Factor Beta Stimulus
Negative Regulation Of Chondrocyte Proliferation
Positive Regulation Of Chondrocyte Hypertrophy
Cellular Response To Leukemia Inhibitory Factor
Negative Regulation Of T-helper 17 Type Immune Response
Negative Regulation Of T-helper 17 Cell Differentiation
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Biological_process
Pathways
Signaling by BMP
Downregulation of TGF-beta receptor signaling
Downregulation of TGF-beta receptor signaling
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
UCH proteinases
Ub-specific processing proteases
Drugs
Diseases
GWAS
Asthma (
32296059
)
Atrial fibrillation (
30061737
29892015
)
Colorectal cancer (
25990418
18372901
18372905
30529582
21761138
17934461
26151821
29228715
30104761
24836286
29471430
24448986
31826910
23266556
)
Colorectal cancer or advanced adenoma (
30510241
)
Coronary artery disease (
33020668
)
Creatinine levels (
29403010
)
Dental caries (
23064961
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Estimated glomerular filtration rate (
31152163
31015462
30604766
)
Glomerular filtration rate (
29403010
)
Heel bone mineral density (
30598549
)
Hematocrit (
32888494
27863252
)
Hemoglobin (
32888494
)
Hemoglobin concentration (
27863252
)
Hemoglobin levels (
32327693
)
Inflammatory bowel disease (
23128233
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Parental longevity (at least one long-lived parent) (
27816938
)
Red blood cell count (
32888494
27863252
)
Height (
31562340
)
Interacting Genes
59 interacting genes:
ACVR1B
AKT1
ASH1L
AXIN1
AXIN2
BMPR1B
CBL
CTNNB1
CXXC5
DVL1
EP300
ERBIN
HAT1
HEYL
KDM2A
MAP2K3
MAP2K6
MAP3K7
MAPK14
MBD1
MRTFB
MYOD1
NEDD4L
OTUD1
PARD3
PIAS1
PIAS4
RLIM
RNF111
SASH3
SETD7
SIRT1
SMAD2
SMAD3
SMAD4
SMAD6
SMURF1
SMURF2
SOX13
SOX5
SOX7
STAMBP
STAMBPL1
STRAP
TAB1
TGFB1I1
TGFBR1
TGFBR2
TTF1
TTF2
UBE2L3
UCHL5
WWP2
XRCC6
YAP1
ZBTB11
ZBTB44
ZEB1
ZNF107
2 interacting genes:
PPP1CA
SMAD7
Entrez ID
4092
27107
HPRD ID
04241
15690
Ensembl ID
ENSG00000101665
ENSG00000066422
Uniprot IDs
B3KYA8
O15105
O95625
Q59H97
PDB IDs
2DJY
2KXQ
2LTV
2LTW
2LTX
2LTY
2LTZ
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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