XAF1 and GLS2

Data Source:
BioGRID (two hybrid)

		XAF1	GLS2
Description		XIAP associated factor 1	glutaminase 2
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GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Cytosol	Mitochondrion Mitochondrial Matrix
	Molecular Function	Protein Binding Zinc Ion Binding	Glutaminase Activity Protein Binding
	Biological Process	Apoptotic Process Response To Interferon-beta Type I Interferon Signaling Pathway	Cellular Amino Acid Metabolic Process Glutamate Biosynthetic Process Glutamine Catabolic Process Cellular Amino Acid Biosynthetic Process Glutamate Secretion Regulation Of Apoptotic Process Reactive Oxygen Species Metabolic Process
Pathways		Interferon alpha/beta signaling	Glutamate Neurotransmitter Release Cycle TP53 Regulates Metabolic Genes Glutamate and glutamine metabolism
Drugs			Glutamic acid
Diseases
GWAS			Adverse response to drug ( 30420678) Amino acid levels ( 26068415) Axial length ( 24144296) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glycine levels ( 30837465) Metabolic traits ( 21886157) Metabolite levels ( 22286219 22916037) Metabolite levels (small molecules and protein measures) ( 27005778) Plasma free amino acid levels ( 30659259) Plasma free amino acid levels (adjusted for one other PFAA) ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Serum metabolite levels ( 31636271 23093944) Serum metabolite levels (CMS) ( 31636271)
Interacting Genes		18 interacting genes: AKT1 APP BIRC7 CREBBP GLS2 LRSAM1 RFC5 RNF114 RNF166 SEPHS1 TP53 TRIM21 TRIM50 TRIM54 TRIML2 UBXN2B VCP XIAP	14 interacting genes: CASK DLG1 DLG2 DLG3 DLG4 GRHPR HIP1 PAG1 PATJ RALA RGS3 SNTA1 TAX1BP3 XAF1
Entrez ID		54739	27165
HPRD ID		06978	05901
Ensembl ID		ENSG00000132530	ENSG00000135423
Uniprot IDs		Q6GPH4	A0A087X004 Q9UI32
PDB IDs		2LXW	4BQM 5U0K
Enriched GO Terms of Interacting Partners?
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