XAF1 and UBXN2B

Data Source:
BioGRID (two hybrid)

		XAF1	UBXN2B
Description		XIAP associated factor 1	UBX domain protein 2B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Cytosol	Nucleus Endoplasmic Reticulum Golgi Apparatus Cytosol Spindle Pole Centrosome
	Molecular Function	Protein Binding Zinc Ion Binding	Protein Binding Ubiquitin Binding
	Biological Process	Apoptotic Process Response To Interferon-beta Type I Interferon Signaling Pathway	Autophagosome Assembly Establishment Of Mitotic Spindle Orientation Golgi Organization Nuclear Envelope Reassembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Mitotic Centrosome Separation Membrane Fusion Negative Regulation Of Protein Localization To Centrosome
Pathways		Interferon alpha/beta signaling
Drugs
Diseases
GWAS			Gallstone disease ( 27094239) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Loneliness ( 27629369) Low density lipoprotein cholesterol levels ( 29403010) Medication use (HMG CoA reductase inhibitors) ( 31015401) Narcolepsy with cataplexy ( 23496005) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Total cholesterol levels ( 29403010) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		18 interacting genes: AKT1 APP BIRC7 CREBBP GLS2 LRSAM1 RFC5 RNF114 RNF166 SEPHS1 TP53 TRIM21 TRIM50 TRIM54 TRIML2 UBXN2B VCP XIAP	14 interacting genes: CRX FAM104A INCA1 MEOX1 MEOX2 NGLY1 PAX5 PAX6 PIN1 PPP1R11 UBXN6 VAT1L VCP XAF1
Entrez ID		54739	137886
HPRD ID		06978	18973
Ensembl ID		ENSG00000132530	ENSG00000215114
Uniprot IDs		Q6GPH4	E5RJ36 Q14CS0
PDB IDs		2LXW
Enriched GO Terms of Interacting Partners?
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