WAPL and RAD21

Data Source:
HPRD (in vivo)

		WAPL	RAD21
Description		WAPL cohesin release factor	RAD21 cohesin complex component
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Chromatin Synaptonemal Complex Nucleus Nucleoplasm Chromosome Cytoplasm Golgi Apparatus Centrosome Cytosol Intercellular Bridge Mitotic Spindle	Chromosome, Centromeric Region Synaptonemal Complex Spindle Pole Nucleoplasm Chromosome Cytosol Cohesin Complex Membrane Nuclear Matrix Nuclear Mitotic Cohesin Complex Nuclear Meiotic Cohesin Complex
	Molecular Function	Protein Binding	Chromatin Binding Protein Binding
	Biological Process	Mitotic Cell Cycle Negative Regulation Of DNA Replication Response To Toxic Substance Viral Process Negative Regulation Of Chromatin Binding Negative Regulation Of Sister Chromatid Cohesion Positive Regulation Of Fibroblast Proliferation Cell Division Regulation Of Chromosome Segregation Regulation Of Chromosome Condensation Protein Localization To Chromatin Regulation Of Cohesin Loading	Double-strand Break Repair DNA Recombination Regulation Of Transcription By RNA Polymerase II Apoptotic Process Mitotic Sister Chromatid Cohesion Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Multicellular Organism Development Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Sister Chromatid Cohesion Cell Division Protein Localization To Chromatin Replication-born Double-strand Break Repair Via Sister Chromatid Exchange
Pathways		Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion	Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Parental longevity (father's age at death) ( 31484785)	Menopause (age at onset) ( 29773799)
Interacting Genes		5 interacting genes: ARAP1 MTNR1A RAD21 SUMO2 XRN1	30 interacting genes: CAPN1 CASP7 CFL1 CSTB DISC1 DYNLT1 FHL3 FLNB HNRNPH2 IL7R MSRB2 MT-CO2 NUMA1 PPP1R15A PPP1R15B PTEN RPL10 RPL13 RPL35A SMARCA5 SMC1A SSU72 STAG1 STAG2 SUMO2 TMSB4X TNFRSF14 WAPL WNT2B ZNF80
Entrez ID		23063	5885
HPRD ID		11072	05924
Ensembl ID		ENSG00000062650	ENSG00000164754
Uniprot IDs		A8K273 B2RTX8 Q7Z5K2	A0A024R9J0 O60216
PDB IDs		4K6J 5HDT	4PJU 4PJW 4PK7 6QNX 6RRC 6RRK 6WG3 6WGE
Enriched GO Terms of Interacting Partners?
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