BRWD1 and NRF1

Data Source:
BioGRID (two hybrid)

		BRWD1	NRF1
Description		bromodomain and WD repeat domain containing 1	nuclear respiratory factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol	Nucleus Nucleoplasm Cytosol Extracellular Exosome
	Molecular Function	Molecular_function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Protein Homodimerization Activity
	Biological Process	Chromatin Organization Regulation Of Transcription By RNA Polymerase II Cytoskeleton Organization Regulation Of Cell Shape Interleukin-7-mediated Signaling Pathway	Regulation Of Transcription By RNA Polymerase II Mitochondrion Organization Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Interleukin-7 signaling Interleukin-7 signaling Chromatin modifying enzymes	PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Transcriptional activation of mitochondrial biogenesis
Drugs
Diseases
GWAS		Adult body size ( 32376654) Apolipoprotein B levels ( 32203549) Cognitive function ( 25644384) Daytime sleep phenotypes ( 27126917) General cognitive ability ( 29844566) LDL cholesterol ( 30275531) Menarche (age at onset) ( 25231870) Platelet distribution width ( 32888494) Temperament (bipolar disorder) ( 22365631) Total cholesterol levels ( 30275531)	Bipolar disorder ( 31043756) Obesity-related traits ( 23251661) Platelet count ( 27863252) Plateletcrit ( 27863252) Red cell distribution width ( 28957414) Response to antidepressants and depression ( 27622933)
Interacting Genes		12 interacting genes: APP APPL1 CALM1 FNDC3B HDAC7 NRF1 NUTF2 SMARCA4 SMARCD1 STAT3 TRIM55 TRIM63	48 interacting genes: AGR2 BBS2 BICRAL BRWD1 C10orf55 C3orf36 CKMT2 COL10A1 CSNK2A1 CSNK2B DYNLL1 ESM1 FHL2 HHIPL1 HIVEP1 KHDC4 KLF15 KPNA5 KRT83 L3MBTL2 L3MBTL3 LHX3 LHX4 LHX6 LMO4 MAFF MVP NDUFAB1 PANX2 PARP1 PLXDC1 POGZ PPARGC1A PPRC1 SIAH2 SLC22A18AS SP2 SP4 SPSB2 SRARP TESMIN TEX43 TOLLIP TRAF2 TRIM35 VEZF1 YPEL3 ZMYM6
Entrez ID		54014	4899
HPRD ID		11683	02930
Ensembl ID		ENSG00000185658	ENSG00000106459
Uniprot IDs		Q9NSI6	A0A024R770 A0A024R774 Q16656
PDB IDs		3Q2E
Enriched GO Terms of Interacting Partners?
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