NRF1 and CKMT2

Data Source:
BioGRID (two hybrid)

		NRF1	CKMT2
Description		nuclear respiratory factor 1	creatine kinase, mitochondrial 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Extracellular Exosome	Mitochondrion Mitochondrial Inner Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Protein Homodimerization Activity	Creatine Kinase Activity Protein Binding ATP Binding Kinase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Mitochondrion Organization Positive Regulation Of Transcription By RNA Polymerase II	Creatine Metabolic Process Muscle Contraction Phosphorylation Phosphocreatine Biosynthetic Process
Pathways		PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Transcriptional activation of mitochondrial biogenesis	Creatine metabolism
Drugs			Creatine Phosphocreatine
Diseases
GWAS		Bipolar disorder ( 31043756) Obesity-related traits ( 23251661) Platelet count ( 27863252) Plateletcrit ( 27863252) Red cell distribution width ( 28957414) Response to antidepressants and depression ( 27622933)
Interacting Genes		48 interacting genes: AGR2 BBS2 BICRAL BRWD1 C10orf55 C3orf36 CKMT2 COL10A1 CSNK2A1 CSNK2B DYNLL1 ESM1 FHL2 HHIPL1 HIVEP1 KHDC4 KLF15 KPNA5 KRT83 L3MBTL2 L3MBTL3 LHX3 LHX4 LHX6 LMO4 MAFF MVP NDUFAB1 PANX2 PARP1 PLXDC1 POGZ PPARGC1A PPRC1 SIAH2 SLC22A18AS SP2 SP4 SPSB2 SRARP TESMIN TEX43 TOLLIP TRAF2 TRIM35 VEZF1 YPEL3 ZMYM6	10 interacting genes: ABHD6 CETN3 ELN KLHL42 LRIF1 NRF1 OLFML3 P4HA3 TMED9 UNC119
Entrez ID		4899	1160
HPRD ID		02930	00425
Ensembl ID		ENSG00000106459	ENSG00000131730
Uniprot IDs		A0A024R770 A0A024R774 Q16656	A0A024RAK5 P17540
PDB IDs			4Z9M
Enriched GO Terms of Interacting Partners?
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