BRWD1 and HDAC7

Data Source:
BioGRID (two hybrid)

		BRWD1	HDAC7
Description		bromodomain and WD repeat domain containing 1	histone deacetylase 7
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Molecular_function	Protein Kinase C Binding Protein Binding Protein Kinase Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Activating Transcription Factor Binding Metal Ion Binding Repressing Transcription Factor Binding 14-3-3 Protein Binding
	Biological Process	Chromatin Organization Regulation Of Transcription By RNA Polymerase II Cytoskeleton Organization Regulation Of Cell Shape Interleukin-7-mediated Signaling Pathway	Protein Deacetylation Negative Regulation Of Interleukin-2 Production Negative Regulation Of Osteoblast Differentiation Histone H3 Deacetylation Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of NIK/NF-kappaB Signaling
Pathways		Interleukin-7 signaling Interleukin-7 signaling Chromatin modifying enzymes	NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants SUMOylation of DNA damage response and repair proteins Notch-HLH transcription pathway Regulation of PTEN gene transcription
Drugs			Trichostatin A Belinostat Panobinostat
Diseases
GWAS		Adult body size ( 32376654) Apolipoprotein B levels ( 32203549) Cognitive function ( 25644384) Daytime sleep phenotypes ( 27126917) General cognitive ability ( 29844566) LDL cholesterol ( 30275531) Menarche (age at onset) ( 25231870) Platelet distribution width ( 32888494) Temperament (bipolar disorder) ( 22365631) Total cholesterol levels ( 30275531)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 31361310 30929738 32296059) Asthma (adult onset) ( 31036433 30929738) Bipolar disorder ( 31043756) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Conjunctival UV autofluorescence (CUVAF) ( 25590795) Diastolic blood pressure ( 27841878) Inflammatory bowel disease ( 28067908) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Primary sclerosing cholangitis ( 23603763) Systolic blood pressure ( 27841878) Ulcerative colitis ( 28067908) Urate levels ( 23263486) White blood cell count ( 32888494)
Interacting Genes		12 interacting genes: APP APPL1 CALM1 FNDC3B HDAC7 NRF1 NUTF2 SMARCA4 SMARCD1 STAT3 TRIM55 TRIM63	59 interacting genes: ACOT11 ACTN4 ANTKMT ARID5A BCL6 BRWD1 C3orf36 CALCOCO2 CASP8 CDC42 CENPQ DDIT4L EDNRA EGFR ESM1 GNG12 GNMT GOLGA6L9 HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 KAT5 KLF16 KRBA2 LDB2 MARK2 MARK3 MEF2A MEF2C MEOX2 MIEN1 NCOR2 NME4 NRIP2 PATJ PHC2 PPARD PPP1R16A PRKD1 PRKD2 RAC1 RAC2 RAC3 REL RIPPLY1 RRAS2 RUNX2 SIN3A SLC16A3 SOGA1 TIAF1 UBE2I UBL3 YPEL3 YWHAG YWHAQ ZBTB16
Entrez ID		54014	51564
HPRD ID		11683	09133
Ensembl ID		ENSG00000185658	ENSG00000061273
Uniprot IDs		Q9NSI6	Q8WUI4
PDB IDs		3Q2E	3C0Y 3C0Z 3C10 3ZNR 3ZNS
Enriched GO Terms of Interacting Partners?
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