NRF1 and TRIM35

Data Source:
BioGRID (two hybrid)

		NRF1	TRIM35
Description		nuclear respiratory factor 1	tripartite motif containing 35
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Extracellular Exosome	Nucleus Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Protein Homodimerization Activity	Molecular_function Zinc Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Mitochondrion Organization Positive Regulation Of Transcription By RNA Polymerase II	Apoptotic Process Protein Ubiquitination Positive Regulation Of Apoptotic Process Innate Immune Response Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Viral Release From Host Cell
Pathways		PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Transcriptional activation of mitochondrial biogenesis	Interferon gamma signaling
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Obesity-related traits ( 23251661) Platelet count ( 27863252) Plateletcrit ( 27863252) Red cell distribution width ( 28957414) Response to antidepressants and depression ( 27622933)	Chronotype ( 30696823) Crohn's disease ( 26192919) Inflammatory bowel disease ( 26192919) Lung cancer ( 28604730)
Interacting Genes		48 interacting genes: AGR2 BBS2 BICRAL BRWD1 C10orf55 C3orf36 CKMT2 COL10A1 CSNK2A1 CSNK2B DYNLL1 ESM1 FHL2 HHIPL1 HIVEP1 KHDC4 KLF15 KPNA5 KRT83 L3MBTL2 L3MBTL3 LHX3 LHX4 LHX6 LMO4 MAFF MVP NDUFAB1 PANX2 PARP1 PLXDC1 POGZ PPARGC1A PPRC1 SIAH2 SLC22A18AS SP2 SP4 SPSB2 SRARP TESMIN TEX43 TOLLIP TRAF2 TRIM35 VEZF1 YPEL3 ZMYM6	49 interacting genes: ADIPOQ BANP CABP2 COL8A1 DTX2 ENKD1 FNDC3B GNMT HNRNPA2B1 IGFN1 KANK2 LCK LMO1 MGAT5B NRF1 PAN2 PARD6B PDCD5 PHF24 PKM PPP2CA PRKAB2 PRR20A PRR20B PRR20C PRR20D PRR20E QARS1 SHC3 SMARCB1 TCEANC TRAPPC6A TRIM10 TRIM11 TRIM5 TRIM55 TRIM63 TSG101 TSSK3 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2K UBE2U UBE2W USP2 USP49 ZNF410
Entrez ID		4899	23087
HPRD ID		02930	15553
Ensembl ID		ENSG00000106459	ENSG00000104228
Uniprot IDs		A0A024R770 A0A024R774 Q16656	E5RGB3 Q9UPQ4
PDB IDs
Enriched GO Terms of Interacting Partners?
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