EXOSC8 and SPATC1L

Data Source:
BioGRID (two hybrid)

		EXOSC8	SPATC1L
Description		exosome component 8	spermatogenesis and centriole associated 1 like
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Fibrillar Center Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Intracellular Membrane-bounded Organelle	Cellular_component Centrosome Sperm Connecting Piece
	Molecular Function	Exoribonuclease Activity Protein Binding MRNA 3'-UTR AU-rich Region Binding Identical Protein Binding	Molecular_function Protein Binding Protein Kinase A Regulatory Subunit Binding
	Biological Process	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing Biological_process RRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U1 SnRNA 3'-end Processing U4 SnRNA 3'-end Processing U5 SnRNA 3'-end Processing Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA Nuclear MRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process Nuclear Polyadenylation-dependent TRNA Catabolic Process Nuclear Polyadenylation-dependent MRNA Catabolic Process	Spermatogenesis Biological_process Actin Polymerization Or Depolymerization Positive Regulation Of Protein Kinase A Signaling Positive Regulation Of CAMP-dependent Protein Kinase Activity
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS
Interacting Genes		74 interacting genes: AEN ATF2 C22orf39 CCDC28A-AS1 CNNM3 COL23A1 COX5A CRMP1 CWC22 DDIT4L DIS3 DUSP23 EXOSC1 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC9 FAM161B FAM90A1 FHOD1 FOXD4L1 FOXN3 FRG1 GEM HAPLN2 HOXB9 INCA1 KANK2 KCNJ11 LMO4 LNX1 LSM1 LSM4 LSM7 MACIR MKRN1 MORN4 MPHOSPH6 MTREX MYOZ1 NEDD9 NTAQ1 OTUD4 PALS2 PHF21A PIAS2 POLDIP3 RASD1 RASSF1 REL RFC5 RPP14 RUSC1 RXRB SLAIN1 SNAI1 SNRPB SNRPC SOCS7 SPATC1L TCEA2 TFAP4 TXNDC17 TXNDC9 UBC UPF2 USP2 USP6 XRN1 XRN2 ZFP36	46 interacting genes: ACOT7 ARL4A ARMC7 ATPAF2 CABP2 DISC1 EXOSC8 FOXN1 FSD2 GOLGA6A GTF3C6 HOOK2 IKZF1 KIFC3 KRT40 KRTAP5-9 LZTS2 MISP MTUS2 MYO15B NCK2 NUTF2 NXF1 PARN PHC2 PHF11 PIAS2 PICK1 PNMA1 POLR1C PPP1CB PPP1CC QARS1 RAD51D RBMY1F RBMY1J REL SIAH1 SYCE1 TCF4 TEKT4 TRIM27 TRMO TSR2 UBL5 ZBTB8B
Entrez ID		11340	84221
HPRD ID		09351	10753
Ensembl ID		ENSG00000120699	ENSG00000160284
Uniprot IDs		Q96B26	Q9H0A9
PDB IDs		2NN6 6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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