FXYD1 and PLPP1

Data Source:
HPRD (in vitro)

		FXYD1	PLPP1
Description		FXYD domain containing ion transport regulator 1	phospholipid phosphatase 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Sodium:potassium-exchanging ATPase Complex Caveola Intercalated Disc Apical Plasma Membrane T-tubule Sarcolemma	Plasma Membrane Integral Component Of Plasma Membrane Caveola Membrane Apical Plasma Membrane Membrane Raft Extracellular Exosome
	Molecular Function	Chloride Channel Activity Sodium Channel Regulator Activity Ion Channel Binding Ion Channel Regulator Activity	Diacylglycerol Diphosphate Phosphatase Activity Protein Binding Phosphatidate Phosphatase Activity Sphingosine-1-phosphate Phosphatase Activity Lipid Phosphatase Activity Ceramide-1-phosphate Phosphatase Activity
	Biological Process	Potassium Ion Transport Sodium Ion Transport Chloride Transport Muscle Contraction Regulation Of Heart Contraction Negative Regulation Of Protein Glutathionylation Ion Transmembrane Transport Regulation Of Cardiac Muscle Cell Membrane Potential Chloride Transmembrane Transport Positive Regulation Of Sodium Ion Export Across Plasma Membrane Regulation Of Cardiac Conduction Regulation Of Sodium Ion Transmembrane Transporter Activity	Phospholipid Metabolic Process Sphingosine Metabolic Process Ceramide Metabolic Process Signal Transduction Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Regulation Of Lipid Metabolic Process Sphingolipid Biosynthetic Process Intracellular Steroid Hormone Receptor Signaling Pathway Androgen Receptor Signaling Pathway Phospholipid Dephosphorylation
Pathways		Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS	Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS			Cocaine dependence ( 31212010) Heel bone mineral density ( 30598549 28869591)
Interacting Genes		9 interacting genes: ATP1A1 ATP1B1 DMPK PAM PLPP1 PPP1CA PRKACA SLC8A1 YWHAQ	5 interacting genes: CREB3 FAHD1 FXYD1 GPR42 SSMEM1
Entrez ID		5348	8611
HPRD ID		03837	06178
Ensembl ID		ENSG00000266964	ENSG00000067113
Uniprot IDs		O00168	A0A024QZS3 A0A024QZU7 O14494
PDB IDs		2J1I 2JO1
Enriched GO Terms of Interacting Partners?
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