PLPP1 and GPR42

Data Source:
BioGRID (two hybrid)

		PLPP1	GPR42
Description		phospholipid phosphatase 1	G protein-coupled receptor 42
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Caveola Membrane Apical Plasma Membrane Membrane Raft Extracellular Exosome	Integral Component Of Plasma Membrane
	Molecular Function	Diacylglycerol Diphosphate Phosphatase Activity Protein Binding Phosphatidate Phosphatase Activity Sphingosine-1-phosphate Phosphatase Activity Lipid Phosphatase Activity Ceramide-1-phosphate Phosphatase Activity	G Protein-coupled Receptor Activity Protein Binding
	Biological Process	Phospholipid Metabolic Process Sphingosine Metabolic Process Ceramide Metabolic Process Signal Transduction Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Regulation Of Lipid Metabolic Process Sphingolipid Biosynthetic Process Intracellular Steroid Hormone Receptor Signaling Pathway Androgen Receptor Signaling Pathway Phospholipid Dephosphorylation	G Protein-coupled Receptor Signaling Pathway
Pathways		Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Cocaine dependence ( 31212010) Heel bone mineral density ( 30598549 28869591)
Interacting Genes		5 interacting genes: CREB3 FAHD1 FXYD1 GPR42 SSMEM1	104 interacting genes: ADIPOQ ALOX5AP ANKRD46 APOD ATP13A1 ATP4B ATP6V0B ATP6V0C BNIP3 BTN2A2 C1GALT1 CCDC167 CCL4L2 CD300C CD79A CLCA4 CLEC2D COMT CTXN3 CXCL16 CXCL9 DRAM1 EFNA5 EMP1 ERMP1 FAM3C FXYD3 FXYD6 GJB2 GOSR2 GPR37L1 GYPC IER3IP1 IGFBP5 IL1RL1 ITGAM JPH1 KCNA1 KLRG1 LAT LEPROTL1 LHFPL5 LNPEP LTC4S MFSD5 MFSD6 MGAM MS4A1 NDUFB11 NINJ2 NRM NSG1 PAEP PLP1 PLPP1 PMP22 PNLIPRP1 RPRM RTP2 RUSF1 SCD SERINC1 SERP2 SERTM1 SLC30A2 SLC30A3 SLC30A8 SLC35E4 SLC38A1 SLC38A7 SLC39A2 SLC41A1 SLC41A2 SMCO4 SMIM3 STATH STRIT1 STX8 SYNDIG1 SYNGR1 TEX264 TF TM4SF4 TMBIM6 TMEM140 TMEM147 TMEM182 TMEM19 TMEM237 TMEM239 TMEM242 TMEM262 TMEM30B TMEM60 TMEM65 TRARG1 TREX1 TSPO2 YIF1A YIPF1 YIPF2 YIPF4 YIPF6 ZFPL1
Entrez ID		8611	2866
HPRD ID		06178	16033
Ensembl ID		ENSG00000067113	ENSG00000126251
Uniprot IDs		A0A024QZS3 A0A024QZU7 O14494	A0A0K0PUY3 O15529
PDB IDs
Enriched GO Terms of Interacting Partners?
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