FXYD1 and DMPK

Data Source:
HPRD (in vitro)

		FXYD1	DMPK
Description		FXYD domain containing ion transport regulator 1	DM1 protein kinase
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Sodium:potassium-exchanging ATPase Complex Caveola Intercalated Disc Apical Plasma Membrane T-tubule Sarcolemma	Nuclear Outer Membrane Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Integral Component Of Mitochondrial Outer Membrane Nuclear Membrane Sarcoplasmic Reticulum Membrane
	Molecular Function	Chloride Channel Activity Sodium Channel Regulator Activity Ion Channel Binding Ion Channel Regulator Activity	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Myosin Phosphatase Regulator Activity Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Potassium Ion Transport Sodium Ion Transport Chloride Transport Muscle Contraction Regulation Of Heart Contraction Negative Regulation Of Protein Glutathionylation Ion Transmembrane Transport Regulation Of Cardiac Muscle Cell Membrane Potential Chloride Transmembrane Transport Positive Regulation Of Sodium Ion Export Across Plasma Membrane Regulation Of Cardiac Conduction Regulation Of Sodium Ion Transmembrane Transporter Activity	Regulation Of Sodium Ion Transport Protein Phosphorylation Cellular Calcium Ion Homeostasis Nuclear Envelope Organization Regulation Of Heart Contraction Muscle Cell Apoptotic Process Regulation Of Myotube Differentiation Regulation Of Skeletal Muscle Contraction By Calcium Ion Signaling Regulation Of Excitatory Postsynaptic Membrane Potential Involved In Skeletal Muscle Contraction Peptidyl-serine Phosphorylation Intracellular Signal Transduction Regulation Of Phosphoprotein Phosphatase Activity Regulation Of Synapse Structural Plasticity Regulation Of Cardiac Conduction
Pathways		Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS	Ion homeostasis
Drugs			Bisindolylmaleimide VIII
Diseases			Myotonic dystrophy (DM)
GWAS			Chronic obstructive pulmonary disease or coronary artery disease (pleiotropy) ( 30940143)
Interacting Genes		9 interacting genes: ATP1A1 ATP1B1 DMPK PAM PLPP1 PPP1CA PRKACA SLC8A1 YWHAQ	18 interacting genes: ANXA7 ATN1 ATXN1 CELF1 FXYD1 GABARAP GEMIN4 HOXA2 HSPB2 PIN1 PLN PPP1R12A RAC1 RAF1 RPS10 SMN1 TK1 UBQLN4
Entrez ID		5348	1760
HPRD ID		03837	05645
Ensembl ID		ENSG00000266964	ENSG00000104936
Uniprot IDs		O00168	B4DM55 B4DZE2 E5KR05 E5KR06 E5KR07 I6L989 Q09013
PDB IDs		2J1I 2JO1	1WT6 2VD5
Enriched GO Terms of Interacting Partners?
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