FXYD1 and PAM

Data Source:
HPRD (in vivo)

		FXYD1	PAM
Description		FXYD domain containing ion transport regulator 1	peptidylglycine alpha-amidating monooxygenase
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Sodium:potassium-exchanging ATPase Complex Caveola Intercalated Disc Apical Plasma Membrane T-tubule Sarcolemma	Extracellular Region Trans-Golgi Network Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Transport Vesicle Membrane Secretory Granule Membrane Neuron Projection Perikaryon Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Chloride Channel Activity Sodium Channel Regulator Activity Ion Channel Binding Ion Channel Regulator Activity	Peptidylglycine Monooxygenase Activity Peptidylamidoglycolate Lyase Activity Copper Ion Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Protein Kinase Binding L-ascorbic Acid Binding Identical Protein Binding
	Biological Process	Potassium Ion Transport Sodium Ion Transport Chloride Transport Muscle Contraction Regulation Of Heart Contraction Negative Regulation Of Protein Glutathionylation Ion Transmembrane Transport Regulation Of Cardiac Muscle Cell Membrane Potential Chloride Transmembrane Transport Positive Regulation Of Sodium Ion Export Across Plasma Membrane Regulation Of Cardiac Conduction Regulation Of Sodium Ion Transmembrane Transporter Activity	Peptide Amidation Response To Hypoxia Long-chain Fatty Acid Metabolic Process Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Heart Development Lactation Response To PH Toxin Metabolic Process Response To Zinc Ion Protein Amidation Protein Phosphopantetheinylation Ovulation Cycle Process Response To Estradiol Regulation Of Actin Cytoskeleton Organization Odontogenesis Response To Drug Response To Copper Ion Regulation Of Protein Secretion Response To Glucocorticoid Maternal Process Involved In Female Pregnancy Limb Development Fatty Acid Primary Amide Biosynthetic Process
Pathways		Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS
Drugs			Ascorbic acid N-Alpha-Acetyl-3,5-Diiodotyrosylglycine N-alpha-Acetyl-3,5-diiodotyrosyl-D-threonine
Diseases
GWAS			Appendicular lean mass ( 33097823) Blood protein levels ( 30072576 29875488) Diastolic blood pressure ( 29208002) Early cardiac repolarization ( 31600170) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Feeling worry ( 29500382) Insulinogenic index ( 23263489) Medication use (drugs used in diabetes) ( 31015401) Nicotine dependence symptom count ( 25555482) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) PR interval ( 30046033 32439900) Primary biliary cholangitis ( 26394269) Refractive error ( 32231278) Sleep duration (short sleep) ( 30846698) Systolic blood pressure ( 29208002) Type 2 diabetes ( 30054458 29358691 30297969 29632382) Type 2 diabetes (adjusted for BMI) ( 29632382)
Interacting Genes		9 interacting genes: ATP1A1 ATP1B1 DMPK PAM PLPP1 PPP1CA PRKACA SLC8A1 YWHAQ	9 interacting genes: CALM1 FXYD1 GLP1R KALRN POMC PRKCA RASSF9 TSC2 UHMK1
Entrez ID		5348	5066
HPRD ID		03837	01361
Ensembl ID		ENSG00000266964	ENSG00000145730
Uniprot IDs		O00168	O43832 P19021
PDB IDs		2J1I 2JO1
Enriched GO Terms of Interacting Partners?
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