FXYD1 and ATP1A1

Data Source:
HPRD (in vivo)

		FXYD1	ATP1A1
Description		FXYD domain containing ion transport regulator 1	ATPase Na+/K+ transporting subunit alpha 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Sodium:potassium-exchanging ATPase Complex Caveola Intercalated Disc Apical Plasma Membrane T-tubule Sarcolemma	Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Sodium:potassium-exchanging ATPase Complex Caveola Postsynaptic Density Intercalated Disc Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane T-tubule Organelle Membrane Protein-containing Complex Sperm Flagellum Sarcolemma Melanosome Membrane Raft Photoreceptor Inner Segment Membrane Extracellular Exosome Extracellular Vesicle
	Molecular Function	Chloride Channel Activity Sodium Channel Regulator Activity Ion Channel Binding Ion Channel Regulator Activity	P-type Sodium:potassium-exchanging ATPase Activity Protein Binding ATP Binding Phosphatase Activity Protein Kinase Binding Protein Domain Specific Binding Ankyrin Binding Potassium Ion Binding Sodium Ion Binding ADP Binding Phosphatidylinositol 3-kinase Binding Protein Heterodimerization Activity Chaperone Binding Steroid Hormone Binding
	Biological Process	Potassium Ion Transport Sodium Ion Transport Chloride Transport Muscle Contraction Regulation Of Heart Contraction Negative Regulation Of Protein Glutathionylation Ion Transmembrane Transport Regulation Of Cardiac Muscle Cell Membrane Potential Chloride Transmembrane Transport Positive Regulation Of Sodium Ion Export Across Plasma Membrane Regulation Of Cardiac Conduction Regulation Of Sodium Ion Transmembrane Transporter Activity	Regulation Of The Force Of Heart Contraction Regulation Of Sodium Ion Transport Cellular Sodium Ion Homeostasis Regulation Of Blood Pressure Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Dephosphorylation Cellular Potassium Ion Homeostasis Negative Regulation Of Glucocorticoid Biosynthetic Process Ion Transmembrane Transport Sodium Ion Export Across Plasma Membrane Response To Drug Negative Regulation Of Heart Contraction Positive Regulation Of Heart Contraction Positive Regulation Of Striated Muscle Contraction Relaxation Of Cardiac Muscle Membrane Hyperpolarization Cellular Response To Mechanical Stimulus Cellular Response To Steroid Hormone Stimulus Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Cardiac Muscle Cell Contraction Membrane Repolarization Membrane Repolarization During Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Proton Transmembrane Transport Response To Glycoside Regulation Of Cardiac Conduction Potassium Ion Import Across Plasma Membrane
Pathways		Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS	Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS
Drugs			Digoxin Acetyldigitoxin Hydroflumethiazide Etacrynic acid Trichlormethiazide Deslanoside Ouabain Diazoxide Bretylium Ciclopirox Bepridil Potassium cation Aluminium Magnesium cation Digitoxin Almitrine Istaroxime Magnesium acetate Potassium acetate Potassium sulfate Potassium Magnesium levulinate Magnesium lactate Aluminium phosphate Aluminum acetate
Diseases
GWAS			Coffee consumption ( 29367735) Macular thickness ( 30535121)
Interacting Genes		9 interacting genes: ATP1A1 ATP1B1 DMPK PAM PLPP1 PPP1CA PRKACA SLC8A1 YWHAQ	18 interacting genes: A2M ADD1 CFL1 EGFR EZH2 FXYD1 FXYD2 FXYD7 GPR35 HGS MAPK1 MAPK3 NDRG1 PRKCA SNAPIN TPT1 ZNRF1 ZNRF2
Entrez ID		5348	476
HPRD ID		03837	01662
Ensembl ID		ENSG00000266964	ENSG00000163399
Uniprot IDs		O00168	P05023
PDB IDs		2J1I 2JO1
Enriched GO Terms of Interacting Partners?
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