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ATP1A1 and EZH2
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
ATP1A1
EZH2
Description
ATPase Na+/K+ transporting subunit alpha 1
enhancer of zeste 2 polycomb repressive complex 2 subunit
Image
No pdb structure
GO Annotations
Cellular Component
Endosome
Endoplasmic Reticulum
Golgi Apparatus
Plasma Membrane
Sodium:potassium-exchanging ATPase Complex
Caveola
Postsynaptic Density
Intercalated Disc
Membrane
Integral Component Of Membrane
Basolateral Plasma Membrane
Apical Plasma Membrane
Lateral Plasma Membrane
T-tubule
Organelle Membrane
Protein-containing Complex
Sperm Flagellum
Sarcolemma
Melanosome
Membrane Raft
Photoreceptor Inner Segment Membrane
Extracellular Exosome
Extracellular Vesicle
Chromosome, Telomeric Region
Chromatin
Nucleus
Nucleoplasm
Chromatin Silencing Complex
Cytoplasm
ESC/E(Z) Complex
Pronucleus
Molecular Function
P-type Sodium:potassium-exchanging ATPase Activity
Protein Binding
ATP Binding
Phosphatase Activity
Protein Kinase Binding
Protein Domain Specific Binding
Ankyrin Binding
Potassium Ion Binding
Sodium Ion Binding
ADP Binding
Phosphatidylinositol 3-kinase Binding
Protein Heterodimerization Activity
Chaperone Binding
Steroid Hormone Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
RNA Polymerase II Transcription Corepressor Binding
Chromatin Binding
Transcription Corepressor Activity
Protein Binding
Protein-lysine N-methyltransferase Activity
Histone-lysine N-methyltransferase Activity
Chromatin DNA Binding
Histone Methyltransferase Activity
Ribonucleoprotein Complex Binding
Histone Methyltransferase Activity (H3-K27 Specific)
Primary MiRNA Binding
Promoter-specific Chromatin Binding
Biological Process
Regulation Of The Force Of Heart Contraction
Regulation Of Sodium Ion Transport
Cellular Sodium Ion Homeostasis
Regulation Of Blood Pressure
Establishment Or Maintenance Of Transmembrane Electrochemical Gradient
Dephosphorylation
Cellular Potassium Ion Homeostasis
Negative Regulation Of Glucocorticoid Biosynthetic Process
Ion Transmembrane Transport
Sodium Ion Export Across Plasma Membrane
Response To Drug
Negative Regulation Of Heart Contraction
Positive Regulation Of Heart Contraction
Positive Regulation Of Striated Muscle Contraction
Relaxation Of Cardiac Muscle
Membrane Hyperpolarization
Cellular Response To Mechanical Stimulus
Cellular Response To Steroid Hormone Stimulus
Cardiac Muscle Cell Action Potential Involved In Contraction
Regulation Of Cardiac Muscle Cell Contraction
Membrane Repolarization
Membrane Repolarization During Cardiac Muscle Cell Action Potential
Cell Communication By Electrical Coupling Involved In Cardiac Conduction
Proton Transmembrane Transport
Response To Glycoside
Regulation Of Cardiac Conduction
Potassium Ion Import Across Plasma Membrane
Negative Regulation Of Transcription By RNA Polymerase II
DNA Methylation
Chromatin Organization
Chromatin Silencing At Telomere
Regulation Of Transcription, DNA-templated
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Epithelial To Mesenchymal Transition
Regulation Of Gliogenesis
Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration
Cardiac Muscle Hypertrophy In Response To Stress
Histone Methylation
Cerebellar Cortex Development
Hippocampus Development
B Cell Differentiation
Response To Estradiol
Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter
Cellular Response To Trichostatin A
Hepatocyte Homeostasis
Regulation Of Circadian Rhythm
Positive Regulation Of MAP Kinase Activity
Negative Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of GTPase Activity
Negative Regulation Of Epidermal Cell Differentiation
Negative Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Retinoic Acid Receptor Signaling Pathway
Cell Development
Rhythmic Process
Negative Regulation Of Striated Muscle Cell Differentiation
Cellular Response To Hydrogen Peroxide
G1 To G0 Transition
Negative Regulation Of G0 To G1 Transition
Histone H3-K27 Methylation
Protein Localization To Chromatin
Positive Regulation Of Protein Serine/threonine Kinase Activity
Liver Regeneration
Histone H3-K27 Trimethylation
Positive Regulation Of Dendrite Development
Positive Regulation Of Cell Cycle G1/S Phase Transition
Response To Tetrachloromethane
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
Ion homeostasis
Ion transport by P-type ATPases
Potential therapeutics for SARS
PRC2 methylates histones and DNA
Oxidative Stress Induced Senescence
PKMTs methylate histone lysines
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Regulation of PTEN gene transcription
Regulation of PTEN gene transcription
Transcriptional Regulation by E2F6
HCMV Early Events
Drugs
Digoxin
Acetyldigitoxin
Hydroflumethiazide
Etacrynic acid
Trichlormethiazide
Deslanoside
Ouabain
Diazoxide
Bretylium
Ciclopirox
Bepridil
Potassium cation
Aluminium
Magnesium cation
Digitoxin
Almitrine
Istaroxime
Magnesium acetate
Potassium acetate
Potassium sulfate
Potassium
Magnesium levulinate
Magnesium lactate
Aluminium phosphate
Aluminum acetate
Tazemetostat
CPI-1205
Diseases
GWAS
Coffee consumption (
29367735
)
Macular thickness (
30535121
)
Chronotype (
30696823
)
Colorectal or endometrial cancer (
26621817
)
Crohn's disease (
28067908
)
Familial squamous cell lung carcinoma (
29924316
)
Height (
25282103
31562340
)
Inflammatory bowel disease (
28067908
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Waist circumference adjusted for BMI (adjusted for smoking behaviour) (
28443625
)
Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) (
28443625
)
Waist circumference adjusted for BMI in non-smokers (
28443625
)
Waist circumference adjusted for body mass index (
25673412
)
Interacting Genes
18 interacting genes:
A2M
ADD1
CFL1
EGFR
EZH2
FXYD1
FXYD2
FXYD7
GPR35
HGS
MAPK1
MAPK3
NDRG1
PRKCA
SNAPIN
TPT1
ZNRF1
ZNRF2
77 interacting genes:
AKT1
AR
ATP1A1
ATP1B1
ATRX
BCL11A
BRCA1
C7orf25
CCDC85B
CDK2
CDK6
CDKN2B-AS1
CEP63
CRY2
DELEC1
DNAJB11
DNMT1
DNMT3A
DNMT3B
E2F6
EED
EHMT1
EPC2
FBXW7
GADD45G
GTF3C1
H1-1
H3-4
H3C1
HDAC1
HOTAIR
JAK2
KAT2B
KLHDC2
KRTAP10-9
LATS2
MAP3K20
MAP3K7
MAPK8IP2
MAPKAPK3
MED1
MELK
MUC1
MYCN
NINL
PFDN1
PHB2
PHF1
PIN4
PJA1
POLA2
PRDM14
PRMT5
PSMB6
RASA1
RBL2
RELA
RELB
RIN3
RPN2
RPS6KA5
SIRT1
SMN1
SMS
SMYD3
SUV39H1
SUZ12
TAF1D
TK1
TNFSF11
TRIM55
TRIM63
USP1
VAV1
WDR61
WSB2
ZMYND11
Entrez ID
476
2146
HPRD ID
01662
03342
Ensembl ID
ENSG00000163399
ENSG00000106462
Uniprot IDs
P05023
A0A090N8E9
Q15910
S4S3R8
PDB IDs
2C6V
4MI0
4MI5
5GSA
5H14
5H15
5H17
5H19
5H24
5H25
5HYN
5IJ7
5IJ8
5LS6
5U5T
5U62
5WG6
5WUK
6C23
6C24
6P5L
6U4Y
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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