DMPK and HSPB2

Data Source:
BioGRID (pull down, two hybrid)
HPRD (two hybrid, in vivo, in vitro)

		DMPK	HSPB2
Description		DM1 protein kinase	heat shock protein family B (small) member 2
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GO Annotations	Cellular Component	Nuclear Outer Membrane Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Integral Component Of Mitochondrial Outer Membrane Nuclear Membrane Sarcoplasmic Reticulum Membrane	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Myosin Phosphatase Regulator Activity Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Structural Constituent Of Eye Lens Protein Binding Enzyme Activator Activity
	Biological Process	Regulation Of Sodium Ion Transport Protein Phosphorylation Cellular Calcium Ion Homeostasis Nuclear Envelope Organization Regulation Of Heart Contraction Muscle Cell Apoptotic Process Regulation Of Myotube Differentiation Regulation Of Skeletal Muscle Contraction By Calcium Ion Signaling Regulation Of Excitatory Postsynaptic Membrane Potential Involved In Skeletal Muscle Contraction Peptidyl-serine Phosphorylation Intracellular Signal Transduction Regulation Of Phosphoprotein Phosphatase Activity Regulation Of Synapse Structural Plasticity Regulation Of Cardiac Conduction	Response To Unfolded Protein Regulation Of Catalytic Activity
Pathways		Ion homeostasis
Drugs		Bisindolylmaleimide VIII
Diseases		Myotonic dystrophy (DM)
GWAS		Chronic obstructive pulmonary disease or coronary artery disease (pleiotropy) ( 30940143)
Interacting Genes		18 interacting genes: ANXA7 ATN1 ATXN1 CELF1 FXYD1 GABARAP GEMIN4 HOXA2 HSPB2 PIN1 PLN PPP1R12A RAC1 RAF1 RPS10 SMN1 TK1 UBQLN4	108 interacting genes: A1CF A2M ABCC9 ABCD4 ACAA2 ACTA1 ACTB ACTC1 ACTG1 AGAP11 ALDH2 ALDOA ASAH1 ATP5F1A ATP6V1E1 B2M BAG3 BEX2 BEX4 BGN BICRAL C1QA CAPZA2 CEP19 CKM CLK4 CMYA5 CRYAA CRYAB CRYGC CTSB CTSD CYP1B1 DCTN1 DCTN6 DDIT4 DMPK DUSP1 EEF1A1 EIF4A2 ENKD1 ENO1 ENO3 ETFA FHL2 FLNC GAPDH GARS1 HADHB HNRNPD HOXB9 HSPB3 HSPB8 KANK2 LGALS1 LMO1 LMO3 MAPKAPK5 MB MCCC2 MDH1 MISP MLF2 MT-CO1 MT-CO2 MT-CO3 MYBPC3 MYH6 MYOM2 MYOZ2 NARS1 NDUFA13 NDUFA6 NT5DC2 PARVA PATZ1 PGM1 PKP2 POGZ PPM1K PRR35 RFPL3 RPL11 RPL36A RPL36AL RPS11 RPS6KA5 RYR2 SDF2 SDHA SLC2A1 SNCA SNU13 SNX18 TATDN1 TCAP THEMIS2 THUMPD2 TLX3 TNNI3 TTN TXNIP UBL5 VEZF1 WDR1 WWOX YPEL3 ZNF335
Entrez ID		1760	3316
HPRD ID		05645	03712
Ensembl ID		ENSG00000104936	ENSG00000170276
Uniprot IDs		B4DM55 B4DZE2 E5KR05 E5KR06 E5KR07 I6L989 Q09013	A8KAH6 Q16082
PDB IDs		1WT6 2VD5	6F2R
Enriched GO Terms of Interacting Partners?
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