GM2A and PLD2

Data Source:
HPRD (in vitro)

		GM2A	PLD2
Description		GM2 ganglioside activator	phospholipase D2
Image
GO Annotations	Cellular Component	Extracellular Region Cytosol Cytoplasmic Side Of Plasma Membrane Basolateral Plasma Membrane Apical Plasma Membrane Azurophil Granule Lumen Lysosomal Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome	Endoplasmic Reticulum Membrane Plasma Membrane Presynapse
	Molecular Function	Lipid Transporter Activity Phospholipase Activator Activity Sphingolipid Activator Protein Activity Beta-N-acetylgalactosaminidase Activity	Phospholipase D Activity Protein Binding Phosphatidylinositol Binding N-acylphosphatidylethanolamine-specific Phospholipase D Activity
	Biological Process	Glycosphingolipid Metabolic Process Ganglioside Catabolic Process Lipid Transport Learning Or Memory Oligosaccharide Catabolic Process Lipid Storage Neutrophil Degranulation Neuromuscular Process Controlling Balance Positive Regulation Of Hydrolase Activity	Phosphatidic Acid Biosynthetic Process Cytoskeleton Organization Small GTPase Mediated Signal Transduction Lipid Catabolic Process Synaptic Vesicle Recycling Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Inositol Lipid-mediated Signaling Cell Motility
Pathways		Glycosphingolipid metabolism Neutrophil degranulation	Synthesis of PG Synthesis of PA Role of phospholipids in phagocytosis
Drugs		Platelet Activating Factor Lauric acid Lpc-Ether Choline alfoscerate Myristic acid	Choline Choline salicylate
Diseases		GM2 gangliosidoses, including: Tay-Sachs disease (type I); Sandhoff disease (type II); Tay-Sachs disease AB variant
GWAS		Bulimia nervosa ( 23568457) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Serum folate levels ( 29953918)	Sphingolipid levels ( 22359512) Systemic lupus erythematosus ( 26502338)
Interacting Genes		3 interacting genes: GPLD1 HEXA PLD2	29 interacting genes: ACTB ACTN1 ALDOA ALDOC AMPH AQP3 ARF1 BIN1 CAV1 CSK DPYSL2 EGFR FYN GAPDH GM2A HIF1A LCK MTDH MTOR OPRM1 PEA15 PIP5K1A PLCG1 PRKCA PRKCD RPTOR SRC STXBP1 VHL
Entrez ID		2760	5338
HPRD ID		02034	03857
Ensembl ID		ENSG00000196743	ENSG00000129219
Uniprot IDs		P17900	O14939
PDB IDs		1G13 1PU5 1PUB 1TJJ 2AF9 2AG2 2AG4 2AG9	6OHM 6OHO 6OHP 6OHQ 6OHS
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?