TDP2 and TNFRSF1B

Data Source:
HPRD (two hybrid, in vivo)

		TDP2	TNFRSF1B
Description		tyrosyl-DNA phosphodiesterase 2	TNF receptor superfamily member 1B
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Aggresome Nuclear Body PML Body	Tumor Necrosis Factor Receptor Superfamily Complex Extracellular Region Nucleus Plasma Membrane Membrane Integral Component Of Membrane Specific Granule Membrane Neuronal Cell Body Varicosity Membrane Raft Perinuclear Region Of Cytoplasm
	Molecular Function	Magnesium Ion Binding Single-stranded DNA Binding Transcription Corepressor Activity Nuclease Activity Protein Binding Manganese Ion Binding Tyrosyl-RNA Phosphodiesterase Activity 5'-tyrosyl-DNA Phosphodiesterase Activity	Tumor Necrosis Factor-activated Receptor Activity Protein Binding Ubiquitin Protein Ligase Binding Tumor Necrosis Factor Binding
	Biological Process	Double-strand Break Repair Cell Surface Receptor Signaling Pathway Viral Process Negative Regulation Of Transcription, DNA-templated Neuron Development Nucleic Acid Phosphodiester Bond Hydrolysis	Regulation Of Cytokine Production Involved In Immune Response Regulation Of T Cell Cytokine Production Aortic Valve Development Pulmonary Valve Development Negative Regulation Of Extracellular Matrix Constituent Secretion Inflammatory Response Aging Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Cardiac Muscle Hypertrophy Cytokine-mediated Signaling Pathway Regulation Of Myelination Positive Regulation Of Myelination Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of T Cell Proliferation Neutrophil Degranulation Positive Regulation Of Oligodendrocyte Differentiation RNA Destabilization Positive Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Cell Death Cellular Response To Lipopolysaccharide Cellular Response To Growth Factor Stimulus Extrinsic Apoptotic Signaling Pathway Regulation Of Neuroinflammatory Response Negative Regulation Of Neuroinflammatory Response Glial Cell-neuron Signaling Negative Regulation Of Neuron Death Positive Regulation Of Apoptotic Process Involved In Morphogenesis Regulation Of RNA Biosynthetic Process
Pathways		Nonhomologous End-Joining (NHEJ)	TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation
Drugs			Tasonermin
Diseases			Graft-versus-host disease
GWAS		Colorectal or endometrial cancer ( 26621817)	Asthma ( 31959851) Blood protein levels ( 30072576 29875488) Blood protein levels in cardiovascular risk ( 28369058) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Tuberculosis ( 29036319) Urate levels (BMI interaction) ( 25811787)
Interacting Genes		35 interacting genes: AKAP9 ATP5MC2 ATXN1 BLK BTBD2 C2orf88 CD40 DLX3 DVL2 EPS8 ETS1 ETS2 FLI1 GOLGA2 JAM2 MAPK6 PSEN1 RAB11A SKIL SMAD3 SNX13 SRPK2 SUMO1 SUMO2 SUMO3 TAP1 TFIP11 TNFRSF1B TNFRSF8 TRAF2 TRAF3 TRAF5 TRAF6 UBE2I WBP2	21 interacting genes: ADAM17 BMX CAV1 CD14 CSNK1A1 CSNK1A1L FANCD2 HIVEP3 KRT18 LTA PKN1 STAT1 TDP2 TNF TRAF1 TRAF2 TRAF3 TRAIP TRIM37 UBQLN1 ZNF420
Entrez ID		51567	7133
HPRD ID		05771	01862
Ensembl ID		ENSG00000111802	ENSG00000028137
Uniprot IDs		A0A384MDM5 O95551	P20333
PDB IDs		5INO 5J3P 5J3S 6Q00 6Q01	1CA9 3ALQ
Enriched GO Terms of Interacting Partners?
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