TDP2 and ATP5MC2

Data Source:
BioGRID (two hybrid)

		TDP2	ATP5MC2
Description		tyrosyl-DNA phosphodiesterase 2	ATP synthase membrane subunit c locus 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Aggresome Nuclear Body PML Body	Mitochondrial Proton-transporting ATP Synthase Complex, Coupling Factor F(o) Mitochondrial Outer Membrane Integral Component Of Membrane Proton-transporting ATP Synthase Complex, Coupling Factor F(o)
	Molecular Function	Magnesium Ion Binding Single-stranded DNA Binding Transcription Corepressor Activity Nuclease Activity Protein Binding Manganese Ion Binding Tyrosyl-RNA Phosphodiesterase Activity 5'-tyrosyl-DNA Phosphodiesterase Activity	Protein Binding Lipid Binding
	Biological Process	Double-strand Break Repair Cell Surface Receptor Signaling Pathway Viral Process Negative Regulation Of Transcription, DNA-templated Neuron Development Nucleic Acid Phosphodiester Bond Hydrolysis	ATP Biosynthetic Process ATP Synthesis Coupled Proton Transport Cristae Formation Mitochondrial ATP Synthesis Coupled Proton Transport
Pathways		Nonhomologous End-Joining (NHEJ)	Formation of ATP by chemiosmotic coupling Cristae formation
Drugs
Diseases
GWAS		Colorectal or endometrial cancer ( 26621817)
Interacting Genes		35 interacting genes: AKAP9 ATP5MC2 ATXN1 BLK BTBD2 C2orf88 CD40 DLX3 DVL2 EPS8 ETS1 ETS2 FLI1 GOLGA2 JAM2 MAPK6 PSEN1 RAB11A SKIL SMAD3 SNX13 SRPK2 SUMO1 SUMO2 SUMO3 TAP1 TFIP11 TNFRSF1B TNFRSF8 TRAF2 TRAF3 TRAF5 TRAF6 UBE2I WBP2	4 interacting genes: ATP13A2 CYSLTR2 TDP2 XRN1
Entrez ID		51567	517
HPRD ID		05771	04429
Ensembl ID		ENSG00000111802	ENSG00000135390
Uniprot IDs		A0A384MDM5 O95551	Q06055
PDB IDs		5INO 5J3P 5J3S 6Q00 6Q01
Enriched GO Terms of Interacting Partners?
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