TDP2 and DLX3

Data Source:
BioGRID (two hybrid)

		TDP2	DLX3
Description		tyrosyl-DNA phosphodiesterase 2	distal-less homeobox 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Aggresome Nuclear Body PML Body	Chromatin Nucleus
	Molecular Function	Magnesium Ion Binding Single-stranded DNA Binding Transcription Corepressor Activity Nuclease Activity Protein Binding Manganese Ion Binding Tyrosyl-RNA Phosphodiesterase Activity 5'-tyrosyl-DNA Phosphodiesterase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Double-strand Break Repair Cell Surface Receptor Signaling Pathway Viral Process Negative Regulation Of Transcription, DNA-templated Neuron Development Nucleic Acid Phosphodiester Bond Hydrolysis	Blood Vessel Development Placenta Development Regulation Of Transcription By RNA Polymerase II Embryo Development Cell Differentiation Epithelial Cell Differentiation Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Transcription By RNA Polymerase II Odontoblast Differentiation
Pathways		Nonhomologous End-Joining (NHEJ)
Drugs
Diseases			Trichodentoosseous dysplasia Amelogenesis imperfecta hypoplastic-hypomaturation with taurodontism (AIHHT)
GWAS		Colorectal or endometrial cancer ( 26621817)	Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701)
Interacting Genes		35 interacting genes: AKAP9 ATP5MC2 ATXN1 BLK BTBD2 C2orf88 CD40 DLX3 DVL2 EPS8 ETS1 ETS2 FLI1 GOLGA2 JAM2 MAPK6 PSEN1 RAB11A SKIL SMAD3 SNX13 SRPK2 SUMO1 SUMO2 SUMO3 TAP1 TFIP11 TNFRSF1B TNFRSF8 TRAF2 TRAF3 TRAF5 TRAF6 UBE2I WBP2	5 interacting genes: BANP POU4F2 PRKCA TBL1X TDP2
Entrez ID		51567	1747
HPRD ID		05771	02752
Ensembl ID		ENSG00000111802	ENSG00000064195
Uniprot IDs		A0A384MDM5 O95551	O60479
PDB IDs		5INO 5J3P 5J3S 6Q00 6Q01	4XRS
Enriched GO Terms of Interacting Partners?
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