TDP2 and BTBD2

Data Source:
BioGRID (two hybrid)

		TDP2	BTBD2
Description		tyrosyl-DNA phosphodiesterase 2	BTB domain containing 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Aggresome Nuclear Body PML Body	P-body Cytosol
	Molecular Function	Magnesium Ion Binding Single-stranded DNA Binding Transcription Corepressor Activity Nuclease Activity Protein Binding Manganese Ion Binding Tyrosyl-RNA Phosphodiesterase Activity 5'-tyrosyl-DNA Phosphodiesterase Activity	Protein Binding
	Biological Process	Double-strand Break Repair Cell Surface Receptor Signaling Pathway Viral Process Negative Regulation Of Transcription, DNA-templated Neuron Development Nucleic Acid Phosphodiester Bond Hydrolysis	Neurogenesis
Pathways		Nonhomologous End-Joining (NHEJ)
Drugs
Diseases
GWAS		Colorectal or endometrial cancer ( 26621817)	Mitochondrial DNA copy number (white blood cells) ( 30704525) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494) Plateletcrit ( 32888494)
Interacting Genes		35 interacting genes: AKAP9 ATP5MC2 ATXN1 BLK BTBD2 C2orf88 CD40 DLX3 DVL2 EPS8 ETS1 ETS2 FLI1 GOLGA2 JAM2 MAPK6 PSEN1 RAB11A SKIL SMAD3 SNX13 SRPK2 SUMO1 SUMO2 SUMO3 TAP1 TFIP11 TNFRSF1B TNFRSF8 TRAF2 TRAF3 TRAF5 TRAF6 UBE2I WBP2	35 interacting genes: BRD7 CCDC90B CCNC CDK2 CINP COPS6 CRMP1 CUL3 DPPA4 EEF1A1 ERG28 GAPDH GBP2 GDF9 IGSF21 KPNA2 MLH1 NGB NTAQ1 OSGIN1 PSMD5 PTN RBM48 SETDB1 SMAD1 SMAD2 TDP2 TGFBR1 TLE1 TOP1 TP53 TRIM5 UBR1 UNC119 ZNF512B
Entrez ID		51567	55643
HPRD ID		05771	12252
Ensembl ID		ENSG00000111802	ENSG00000133243
Uniprot IDs		A0A384MDM5 O95551	Q9BX70
PDB IDs		5INO 5J3P 5J3S 6Q00 6Q01	3NO8
Enriched GO Terms of Interacting Partners?
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