H2AC20 and USP12

Data Source:
BioGRID (enzymatic study)

		H2AC20	USP12
Description		H2A clustered histone 20	ubiquitin specific peptidase 12
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GO Annotations	Cellular Component	Nucleosome Nucleus Extracellular Exosome	Cellular_component Nucleus Nucleoplasm Cytosol
	Molecular Function	Molecular_function DNA Binding Protein Heterodimerization Activity	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Metal Ion Binding
	Biological Process	Chromatin Silencing Biological_process	Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination Protein Phosphopantetheinylation
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 UCH proteinases Ub-specific processing proteases Metalloprotease DUBs Deposition of new CENPA-containing nucleosomes at the centromere RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Amyloid fiber formation	Ub-specific processing proteases
Drugs
Diseases
GWAS			Alcohol dependence ( 21314694) Anti-saccade response ( 29064472) Mortality in sepsis ( 27639821) Nose morphology ( 29921221) Ulcerative colitis ( 19915573)
Interacting Genes		74 interacting genes: ANP32A APP ATXN7L3 BAP1 BARD1 BMI1 BRCA1 CDY1 CRP CSTF1 CTCFL DDB2 DNMT3L EIF2AK2 EP300 ESR1 FBL GATAD2A GATAD2B H2BC1 H2BC21 H3C1 H4C1 H4C14 HAT1 HDAC2 KAT2A KAT2B KAT5 KAT7 MSL2 MYSM1 NAA40 NAP1L4 NCAPH NCL NPM1 PARP10 PBRM1 PELP1 POT1 PRMT5 PRMT7 RAG1 RBBP4 RCC1 RNF168 RNF2 RNF20 RNF8 SART3 SIRT7 SSRP1 STK38 TAF15 TAF1A TAF1B TCF20 TRIM37 TSPY1 TSSK6 UBC UBE2B UBR2 UIMC1 USP10 USP12 USP16 USP2 USP22 USP46 USP51 USP7 USP8	6 interacting genes: APP H2AC20 H2BC21 NOTCH1 UBC WDR20
Entrez ID		8338	219333
HPRD ID		09107	15631
Ensembl ID		ENSG00000184260	ENSG00000152484
Uniprot IDs		Q16777	O75317
PDB IDs		6Y5E	5K16 5K1A 5K1B 5K1C 5L8W
Enriched GO Terms of Interacting Partners?
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