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KRT34 and PSMB1
Data Source:
BioGRID
(two hybrid)
KRT34
PSMB1
Description
keratin 34
proteasome 20S subunit beta 1
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Space
Cytosol
Intermediate Filament
Proteasome Complex
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Proteasome Core Complex
Proteasome Core Complex, Beta-subunit Complex
Secretory Granule Lumen
Extracellular Exosome
Ficolin-1-rich Granule Lumen
Molecular Function
Structural Molecule Activity
Protein Binding
Endopeptidase Activity
Threonine-type Endopeptidase Activity
Protein Binding
Biological Process
Epidermis Development
Keratinization
Cornification
MAPK Cascade
Protein Polyubiquitination
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Regulation Of Cellular Amino Acid Metabolic Process
Proteasomal Ubiquitin-independent Protein Catabolic Process
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Viral Process
Protein Deubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tumor Necrosis Factor-mediated Signaling Pathway
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Neutrophil Degranulation
Regulation Of MRNA Stability
Post-translational Protein Modification
T Cell Receptor Signaling Pathway
Transmembrane Transport
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Interleukin-1-mediated Signaling Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Hematopoietic Stem Cell Differentiation
Pathways
Keratinization
Formation of the cornified envelope
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
Neutrophil degranulation
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Bortezomib
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE
Carfilzomib
Diseases
GWAS
Blood protein levels (
30072576
)
Type 1 diabetes (
21980299
)
Interacting Genes
253 interacting genes:
A1CF
ABHD15
ABI2
ADRA2C
AGXT
AIMP2
ALDH3B1
AMOT
ANKRD11
ANKS1A
ARMC7
ASMTL
ATG9A
ATPAF2
BATF2
BCAS2
BEX1
BEX2
BEX3
BHLHE23
BOLA3
BRME1
C11orf87
C17orf50
C1orf216
C5orf49
CBX8
CCDC120
CCDC13
CCDC146
CCDC196
CCDC198
CCDC24
CCDC28A-AS1
CCHCR1
CCNC
CDC20B
CDK18
CERK
CFAP206
CFAP53
CHRD
CHRNG
CLCNKA
CLDN19
CLEC18A
CTRC
CWC25
CYSRT1
CYTH4
DCTN3
DDIT4L
DDX6
DHRS1
DMRT3
DOCK2
EFCAB3
EIF4G1
EPDR1
EXOC8
EXOSC5
FAM110A
FAM214B
FAM50B
FAM71C
FAM83A
FAM90A1
FARS2
FBXW5
FNDC11
FOXD4L1
FRS3
GADD45GIP1
GAST
GATAD2A
GEM
GLYCTK
GNE
GNG10
GNG13
GPS2
GRN
GSC2
GSTP1
HAPLN2
HBA1
HBA2
HCK
HDAC4
HGS
HOXA1
HOXB5
HOXB9
HOXC8
HSPA12B
HSPD1
HYAL2
ICAM4
INIP
INO80B
ISCU
ITGB5
ITPKB
JOSD1
KANK2
KCTD9
KDELR1
KIDINS220
KLC4
KLHL38
KLK8
KRT1
KRT20
KRT3
KRT6A
KRT6C
KRT71
KRT74
KRT75
KRT78
KRT79
KRT8
KRT80
KRT81
KRT82
KRT83
KRT85
KRT86
KRTAP12-2
KRTAP13-1
KRTAP19-5
KRTAP19-7
KRTAP26-1
LMO2
LMO4
LRRC29
LRRC41
LYSMD1
LYVE1
MAB21L2
MAD2L2
MAP3K7CL
MAPKBP1
MATR3
MBD3L2
METTL17
MIDN
MIIP
MKRN3
MNS1
MOS
MSRB3
MYO15B
MYOZ1
MYOZ3
NAB2
NAXD
NEK6
NFKBID
NMU
NOTO
NPBWR2
NUP42
P2RX7
PDE9A
PDGFRB
PGLYRP3
PIN1
PITX1
PITX2
PKN1
PLLP
POP5
PPP1R18
PPP1R27
PPP3R2
PRPF18
PRPF31
PRR19
PRR35
PSMA1
PSMB1
PTPMT1
R3HDM2
RAB33A
RAB3IL1
RASD1
RFC5
RIN1
RIPPLY1
RTP5
SAMD11
SCNM1
SEC14L4
SEMA4C
SHC3
SIRPA
SLC15A2
SLC22A5
SLC23A1
SLC25A42
SMARCD1
SMARCE1
SMCP
SMG9
SNRPB
SPAG8
SPATA46
SPRY3
STMN3
SUOX
TACO1
TAPBPL
TBC1D22B
TCHP
TEKT3
TEKT4
TENT5B
TEPSIN
TFAP2D
THAP7
TLE5
TLX3
TMEM174
TMIE
TMSB4X
TRARG1
TRIM42
TRIM73
TRIML2
TSG101
TTC23
TTC9C
TXLNA
TXLNB
USP2
UTP14C
UTP23
VENTX
WDR25
WWOX
ZDHHC1
ZFHX3
ZFYVE26
ZIC1
ZNF124
ZNF148
ZNF319
ZNF414
ZNF446
ZNF580
ZNF581
ZNF79
105 interacting genes:
AGR2
AHSP
ARNT2
BEND7
BIRC7
BPIFA1
CAMK2G
CCM2L
CDC14B
CDC42
CDKN1B
CLPP
COG6
CTAG1A
CTAG1B
CYTH4
DCP2
DDI1
EXOSC6
FAM136A
FAM50B
FANCG
GADD45GIP1
GEMIN2
GEMIN4
GPBP1
GRIPAP1
GTPBP2
HMG20A
HOXA1
IMPACT
INSIG2
JAKMIP1
KATNBL1
KHDC4
KIFC3
KRT13
KRT15
KRT31
KRT34
KRT36
KRT40
KRTAP15-1
KRTAP19-1
KRTAP19-7
KRTAP7-1
LCE1C
LCE1F
LDB2
LENG1
LHX3
LIN7B
LMO1
LZTFL1
MAPRE3
MKRN3
MLKL
MRNIP
MTUS2
NANOS3
NME4
OIP5
OTUD7B
PIP4K2B
PLEKHG4
PLK1
POMP
PSEN1
PSMA1
PSMB3
PSMB4
PSMB5
PSMB7
PSMG3
PYCR3
RIPPLY3
RNF8
RPRD1B
RWDD2A
RYBP
SCARA5
SERPINB2
SH3GL1
SMAD3
SMARCB1
STMN2
TFPT
THAP6
TLE5
TOLLIP
TRAF1
TRAF2
TRIM23
TRIM27
TRIM39
TTC33
UBASH3B
VAX1
XPA
ZBTB32
ZNF177
ZNF438
ZNF559-ZNF177
ZNF688
ZNF774
Entrez ID
3885
5689
HPRD ID
04137
03603
Ensembl ID
ENSG00000131737
ENSG00000008018
Uniprot IDs
O76011
A0A140VK45
P20618
PDB IDs
4R3O
4R67
5A0Q
5GJQ
5GJR
5L4G
5L5B
5L5D
5L5E
5L5F
5L5H
5L5I
5L5J
5L5O
5L5P
5L5Q
5L5R
5L5S
5L5T
5L5U
5L5V
5L5W
5L5X
5L5Y
5L5Z
5L60
5L61
5L62
5L63
5L64
5LE5
5LEX
5LEY
5LEZ
5LF0
5LF1
5LF3
5LF4
5LF6
5LF7
5LN3
5M2B
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFO
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
6AVO
6E5B
6KWY
6MSB
6MSD
6MSE
6MSG
6MSH
6MSJ
6MSK
6R70
6REY
6RGQ
6WJD
6WJN
6XMJ
Enriched GO Terms of Interacting Partners
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