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KRT34 and HCK
Data Source:
BioGRID
(two hybrid)
KRT34
HCK
Description
keratin 34
HCK proto-oncogene, Src family tyrosine kinase
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Space
Cytosol
Intermediate Filament
Nucleus
Lysosome
Golgi Apparatus
Cytosol
Actin Filament
Plasma Membrane
Caveola
Focal Adhesion
Transport Vesicle
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Cell Projection
Intracellular Membrane-bounded Organelle
Molecular Function
Structural Molecule Activity
Protein Binding
Phosphotyrosine Residue Binding
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Signaling Receptor Binding
Protein Binding
ATP Binding
Biological Process
Epidermis Development
Keratinization
Cornification
Leukocyte Migration Involved In Immune Response
Innate Immune Response-activating Signal Transduction
Protein Phosphorylation
Inflammatory Response
Cell Adhesion
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Integrin-mediated Signaling Pathway
Mesoderm Development
Positive Regulation Of Cell Population Proliferation
Regulation Of Cell Shape
Peptidyl-tyrosine Phosphorylation
Cytokine-mediated Signaling Pathway
Cell Differentiation
Positive Regulation Of Actin Filament Polymerization
Lipopolysaccharide-mediated Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Negative Regulation Of Apoptotic Process
Leukocyte Degranulation
Innate Immune Response
Respiratory Burst After Phagocytosis
Protein Autophosphorylation
Regulation Of Defense Response To Virus By Virus
Regulation Of Inflammatory Response
Regulation Of Phagocytosis
Regulation Of DNA-binding Transcription Factor Activity
Interferon-gamma-mediated Signaling Pathway
Regulation Of Podosome Assembly
Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways
Keratinization
Formation of the cornified envelope
Nef and signal transduction
FCGR activation
Regulation of signaling by CBL
Regulation of signaling by CBL
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated phagocytosis
FLT3 signaling through SRC family kinases
Drugs
1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine
Phosphonotyrosine
Quercetin
Bosutinib
Fostamatinib
Diseases
GWAS
Adult body size (
32376654
)
Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) (
30940143
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Inflammatory bowel disease (
23128233
)
Migraine (
27322543
)
Interacting Genes
253 interacting genes:
A1CF
ABHD15
ABI2
ADRA2C
AGXT
AIMP2
ALDH3B1
AMOT
ANKRD11
ANKS1A
ARMC7
ASMTL
ATG9A
ATPAF2
BATF2
BCAS2
BEX1
BEX2
BEX3
BHLHE23
BOLA3
BRME1
C11orf87
C17orf50
C1orf216
C5orf49
CBX8
CCDC120
CCDC13
CCDC146
CCDC196
CCDC198
CCDC24
CCDC28A-AS1
CCHCR1
CCNC
CDC20B
CDK18
CERK
CFAP206
CFAP53
CHRD
CHRNG
CLCNKA
CLDN19
CLEC18A
CTRC
CWC25
CYSRT1
CYTH4
DCTN3
DDIT4L
DDX6
DHRS1
DMRT3
DOCK2
EFCAB3
EIF4G1
EPDR1
EXOC8
EXOSC5
FAM110A
FAM214B
FAM50B
FAM71C
FAM83A
FAM90A1
FARS2
FBXW5
FNDC11
FOXD4L1
FRS3
GADD45GIP1
GAST
GATAD2A
GEM
GLYCTK
GNE
GNG10
GNG13
GPS2
GRN
GSC2
GSTP1
HAPLN2
HBA1
HBA2
HCK
HDAC4
HGS
HOXA1
HOXB5
HOXB9
HOXC8
HSPA12B
HSPD1
HYAL2
ICAM4
INIP
INO80B
ISCU
ITGB5
ITPKB
JOSD1
KANK2
KCTD9
KDELR1
KIDINS220
KLC4
KLHL38
KLK8
KRT1
KRT20
KRT3
KRT6A
KRT6C
KRT71
KRT74
KRT75
KRT78
KRT79
KRT8
KRT80
KRT81
KRT82
KRT83
KRT85
KRT86
KRTAP12-2
KRTAP13-1
KRTAP19-5
KRTAP19-7
KRTAP26-1
LMO2
LMO4
LRRC29
LRRC41
LYSMD1
LYVE1
MAB21L2
MAD2L2
MAP3K7CL
MAPKBP1
MATR3
MBD3L2
METTL17
MIDN
MIIP
MKRN3
MNS1
MOS
MSRB3
MYO15B
MYOZ1
MYOZ3
NAB2
NAXD
NEK6
NFKBID
NMU
NOTO
NPBWR2
NUP42
P2RX7
PDE9A
PDGFRB
PGLYRP3
PIN1
PITX1
PITX2
PKN1
PLLP
POP5
PPP1R18
PPP1R27
PPP3R2
PRPF18
PRPF31
PRR19
PRR35
PSMA1
PSMB1
PTPMT1
R3HDM2
RAB33A
RAB3IL1
RASD1
RFC5
RIN1
RIPPLY1
RTP5
SAMD11
SCNM1
SEC14L4
SEMA4C
SHC3
SIRPA
SLC15A2
SLC22A5
SLC23A1
SLC25A42
SMARCD1
SMARCE1
SMCP
SMG9
SNRPB
SPAG8
SPATA46
SPRY3
STMN3
SUOX
TACO1
TAPBPL
TBC1D22B
TCHP
TEKT3
TEKT4
TENT5B
TEPSIN
TFAP2D
THAP7
TLE5
TLX3
TMEM174
TMIE
TMSB4X
TRARG1
TRIM42
TRIM73
TRIML2
TSG101
TTC23
TTC9C
TXLNA
TXLNB
USP2
UTP14C
UTP23
VENTX
WDR25
WWOX
ZDHHC1
ZFHX3
ZFYVE26
ZIC1
ZNF124
ZNF148
ZNF319
ZNF414
ZNF446
ZNF580
ZNF581
ZNF79
116 interacting genes:
ABL1
ABL2
ACTB
ADAM15
AGK
AGR2
APP
AR
ARRB1
ASAP1
BCAR1
BCR
BPIFA1
BTK
CBL
CCDC88B
CCR3
CD2AP
CHST15
CREBBP
CSF2RB
CSF3R
CSK
CTAG1A
CTAG1B
CYB5D2
CYSRT1
DNM2
DOK1
DOK2
EGFR
ELMO1
ERBB2
ERBB3
ERBB4
EVL
FASLG
FCGR1A
FCGR2A
FHL2
FHL5
GAB1
GOPC
GRB14
HNRNPK
HSF2BP
IL6ST
INCA1
INPP5D
IRF2BPL
KHDRBS1
KIT
KPRP
KRT31
KRT34
KRT35
KRT36
KRT40
KRTAP1-1
KRTAP1-3
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP3-1
LCP2
LETMD1
LMNA
MAP4K5
MDK
MDM2
MET
MID2
MKRN3
MTUS2
NBPF19
NGEF
NOTCH2NLA
PAK2
PECAM1
PIK3CB
PIK3R1
PIK3R2
PLAUR
PLCG1
PLCG2
PLEKHG4
PNMA1
RAPGEF1
RASA1
RASA3
RBPMS
RPL10
SF3B3
SH2B2
SH3BP1
SH3KBP1
SKAP2
SOS1
SPRR2A
STAT3
TEKT4
TEPSIN
TNK2
TOX2
TP73
TRIM27
TRIP6
TRPV4
TSG101
UNC119
VAV1
WAS
WDCP
WIPF1
WNT2
ZSCAN4
Entrez ID
3885
3055
HPRD ID
04137
00796
Ensembl ID
ENSG00000131737
ENSG00000101336
Uniprot IDs
O76011
A8K4G3
P08631
PDB IDs
1AD5
1BU1
1QCF
2C0I
2C0O
2C0T
2HCK
2HK5
2OI3
2OJ2
3HCK
3NHN
3RBB
3REA
3REB
3VRY
3VRZ
3VS0
3VS1
3VS2
3VS3
3VS4
3VS5
3VS6
3VS7
4HCK
4LUD
4LUE
4ORZ
4U5W
5H09
5H0B
5H0E
5H0G
5H0H
5HCK
5NUH
5ZJ6
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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