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KRT34 and FRS3
Data Source:
BioGRID
(two hybrid)
KRT34
FRS3
Description
keratin 34
fibroblast growth factor receptor substrate 3
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Space
Cytosol
Intermediate Filament
Plasma Membrane
Molecular Function
Structural Molecule Activity
Protein Binding
Fibroblast Growth Factor Receptor Binding
Protein Binding
Identical Protein Binding
Biological Process
Epidermis Development
Keratinization
Cornification
MAPK Cascade
Signal Transduction
Fibroblast Growth Factor Receptor Signaling Pathway
Pathways
Keratinization
Formation of the cornified envelope
FRS-mediated FGFR1 signaling
FRS-mediated FGFR2 signaling
FRS-mediated FGFR3 signaling
FRS-mediated FGFR4 signaling
RAF/MAP kinase cascade
Activated NTRK2 signals through FRS2 and FRS3
Drugs
Diseases
GWAS
Menarche (age at onset) (
25231870
)
Interacting Genes
253 interacting genes:
A1CF
ABHD15
ABI2
ADRA2C
AGXT
AIMP2
ALDH3B1
AMOT
ANKRD11
ANKS1A
ARMC7
ASMTL
ATG9A
ATPAF2
BATF2
BCAS2
BEX1
BEX2
BEX3
BHLHE23
BOLA3
BRME1
C11orf87
C17orf50
C1orf216
C5orf49
CBX8
CCDC120
CCDC13
CCDC146
CCDC196
CCDC198
CCDC24
CCDC28A-AS1
CCHCR1
CCNC
CDC20B
CDK18
CERK
CFAP206
CFAP53
CHRD
CHRNG
CLCNKA
CLDN19
CLEC18A
CTRC
CWC25
CYSRT1
CYTH4
DCTN3
DDIT4L
DDX6
DHRS1
DMRT3
DOCK2
EFCAB3
EIF4G1
EPDR1
EXOC8
EXOSC5
FAM110A
FAM214B
FAM50B
FAM71C
FAM83A
FAM90A1
FARS2
FBXW5
FNDC11
FOXD4L1
FRS3
GADD45GIP1
GAST
GATAD2A
GEM
GLYCTK
GNE
GNG10
GNG13
GPS2
GRN
GSC2
GSTP1
HAPLN2
HBA1
HBA2
HCK
HDAC4
HGS
HOXA1
HOXB5
HOXB9
HOXC8
HSPA12B
HSPD1
HYAL2
ICAM4
INIP
INO80B
ISCU
ITGB5
ITPKB
JOSD1
KANK2
KCTD9
KDELR1
KIDINS220
KLC4
KLHL38
KLK8
KRT1
KRT20
KRT3
KRT6A
KRT6C
KRT71
KRT74
KRT75
KRT78
KRT79
KRT8
KRT80
KRT81
KRT82
KRT83
KRT85
KRT86
KRTAP12-2
KRTAP13-1
KRTAP19-5
KRTAP19-7
KRTAP26-1
LMO2
LMO4
LRRC29
LRRC41
LYSMD1
LYVE1
MAB21L2
MAD2L2
MAP3K7CL
MAPKBP1
MATR3
MBD3L2
METTL17
MIDN
MIIP
MKRN3
MNS1
MOS
MSRB3
MYO15B
MYOZ1
MYOZ3
NAB2
NAXD
NEK6
NFKBID
NMU
NOTO
NPBWR2
NUP42
P2RX7
PDE9A
PDGFRB
PGLYRP3
PIN1
PITX1
PITX2
PKN1
PLLP
POP5
PPP1R18
PPP1R27
PPP3R2
PRPF18
PRPF31
PRR19
PRR35
PSMA1
PSMB1
PTPMT1
R3HDM2
RAB33A
RAB3IL1
RASD1
RFC5
RIN1
RIPPLY1
RTP5
SAMD11
SCNM1
SEC14L4
SEMA4C
SHC3
SIRPA
SLC15A2
SLC22A5
SLC23A1
SLC25A42
SMARCD1
SMARCE1
SMCP
SMG9
SNRPB
SPAG8
SPATA46
SPRY3
STMN3
SUOX
TACO1
TAPBPL
TBC1D22B
TCHP
TEKT3
TEKT4
TENT5B
TEPSIN
TFAP2D
THAP7
TLE5
TLX3
TMEM174
TMIE
TMSB4X
TRARG1
TRIM42
TRIM73
TRIML2
TSG101
TTC23
TTC9C
TXLNA
TXLNB
USP2
UTP14C
UTP23
VENTX
WDR25
WWOX
ZDHHC1
ZFHX3
ZFYVE26
ZIC1
ZNF124
ZNF148
ZNF319
ZNF414
ZNF446
ZNF580
ZNF581
ZNF79
111 interacting genes:
ADAMTSL4
ANAPC11
ANKRD55
ATP23
BLZF1
BMPR2
C11orf1
C11orf45
C19orf54
C22orf39
CATSPER1
CBY2
CCDC33
CCN3
CDPF1
COL8A1
COPS3
CREB5
CYSRT1
DCDC2B
DDX5
DMRT3
DPEP2NB
ECM1
ESM1
FGFR1
GATA1
GPRIN2
GRB14
GRB2
HOXA1
HOXD12
ID2
ID3
IKZF3
INCA1
ISY1-RAB43
KARS1
KATNBL1
KIAA0408
KPRP
KRT31
KRT33B
KRT34
KRT35
KRT76
KRTAP1-1
KRTAP10-8
KRTAP11-1
KRTAP3-1
KRTAP3-2
KRTAP6-2
LINGO1
LRRC18
MAPK1
MATK
MBD3L1
MIIP
NADSYN1
NBPF19
NOTCH2NLA
NTRK1
NTRK2
NUMB
PCSK5
PDLIM7
PIH1D2
PLB1
PLLP
PLSCR1
POF1B
PPP1R32
PRDM6
PRKCI
PTPN11
RFX6
RIMBP3C
RND1
SCNM1
SH2B1
SLAIN1
SLC22A18AS
SOCS6
SPATA12
SPRY2
STH
STK16
TCF4
TCP10L
TGM7
TLE5
TNS1
TRAF4
TRIP6
TSC1
TSGA10IP
TSPAN4
UNKL
VASP
VGLL3
WDR83
WWOX
YPEL3
ZMIZ2
ZNF124
ZNF417
ZNF438
ZNF446
ZNF552
ZNF69
ZSCAN30
Entrez ID
3885
10817
HPRD ID
04137
06373
Ensembl ID
ENSG00000131737
ENSG00000137218
Uniprot IDs
O76011
A0A140VJJ7
O43559
PDB IDs
2KUP
2KUQ
2YS5
2YT2
Enriched GO Terms of Interacting Partners
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