MS4A4A and PLP1

Data Source:
BioGRID (two hybrid)

		MS4A4A	PLP1
Description		membrane spanning 4-domains A4A	proteolipid protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Membrane Plasma Membrane Raft	Plasma Membrane Integrin Alphav-beta3 Complex Myelin Sheath Synapse
	Molecular Function	Protein Binding	Structural Molecule Activity Protein Binding Structural Constituent Of Myelin Sheath
	Biological Process		Inflammatory Response Chemical Synaptic Transmission Axon Ensheathment Positive Regulation Of Gene Expression Astrocyte Development Substantia Nigra Development Central Nervous System Myelination Positive Regulation Of Cell Migration Neuron Projection Development Long-chain Fatty Acid Biosynthetic Process Axon Development AMPA Selective Glutamate Receptor Signaling Pathway Positive Regulation Of Calcium Ion Transmembrane Transport
Pathways
Drugs
Diseases			Hereditary spastic paraplegia (SPG) Hypomyelinating leukodystrophy (HLD); Pelizaeus-Merzbacher disease (PMD)
GWAS		Alzheimer's disease (late onset) ( 21460841) Alzheimer's disease in APOE e4- carriers ( 25778476) C-reactive protein levels ( 30388399) Cerebrospinal fluid sTREM-2 levels ( 31413141) Fibrinogen levels ( 28107422)
Interacting Genes		14 interacting genes: ATP6V0E1 CLDN19 CMTM7 LPAR3 MAL NRG1 PLP1 RPRM RUSF1 SEC22A SERTM1 TMEM14B TMUB2 UPK1B	86 interacting genes: ADGRG3 AKT1 AQP10 AQP6 ARL13B BCL2L13 BIK CALN1 CALR CANX CD40 CD74 CDIPT CLDN2 CLDN20 CLEC2D CLN8 CREB3 CREB3L1 CYBC1 DCT DYSF EDA2R ELOVL4 ERGIC3 FAM209A FCRL2 FFAR2 FNDC9 GAST GPR42 GPR61 HAS3 HTR2C IER3IP1 IFITM3 ITGAV JAGN1 JPH1 KLRC1 LEPROTL1 LEUTX LHFPL5 LMNA MAG MBP MFF MGST3 MS4A3 MS4A4A MTIF3 MUC1 MYADM NRG1 PI16 PIGP PTPRN RELL2 RMDN3 RNF24 SLC10A6 SLC16A2 SLC18A1 SLC1A5 SLC26A6 SLC35E2A SLC35E3 SLC41A3 SMIM3 SPNS3 STX1A STX4 SUSD3 TMEM106C TMEM14B TMEM182 TMEM242 TMEM243 TMEM254 TMEM31 TMEM45B TMEM52B TMEM97 TMPRSS2 UPK2 VAT1
Entrez ID		51338	5354
HPRD ID		08408	02321
Ensembl ID		ENSG00000110079	ENSG00000123560
Uniprot IDs		A0A384MDW1 Q4JF27 Q96JQ5	A0A0S2Z4D4 A8K9L3 B4DI30 P60201
PDB IDs			2XPG
Enriched GO Terms of Interacting Partners?
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