PLEKHO1 and IFI35

Data Source:
BioGRID (two hybrid)

		PLEKHO1	IFI35
Description		pleckstrin homology domain containing O1	interferon induced protein 35
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Ruffle Membrane Muscle Cell Projection Membrane	Extracellular Space Nucleus Cytoplasm Cytosol Membrane
	Molecular Function	Protein Binding	Protein Binding Identical Protein Binding
	Biological Process	Myoblast Fusion Regulation Of Cell Shape Myoblast Migration Lamellipodium Morphogenesis	Macrophage Activation Involved In Immune Response Negative Regulation Of Cell Population Proliferation Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Innate Immune Response Positive Regulation Of Inflammatory Response Type I Interferon Signaling Pathway Negative Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of NIK/NF-kappaB Signaling
Pathways			Interferon alpha/beta signaling
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)	Coronary artery disease ( 29212778)
Interacting Genes		32 interacting genes: ADAM33 AKT1 AKT2 BNIP2 BRICD5 C10orf88 C4orf3 CEP19 COL8A2 CSNK2A1 CYP4F2 DNAJB1 FLNB IFI35 LRP10 MMD NAPB PSMC5 RPS20 SMAD5 SMURF1 THSD7B TMEM218 TNF TRAF3IP3 TRAF6 TRAM1L1 TSPAN33 TSPO2 USP7 VAMP3 ZFPL1	12 interacting genes: BATF BCAS2 CLEC4G CYTH3 EML2 FHL2 KDM1A MAPK1 NMI PLEKHO1 TRIM55 TRIM63
Entrez ID		51177	3430
HPRD ID		12217	02844
Ensembl ID		ENSG00000023902	ENSG00000068079
Uniprot IDs		Q53GL0 Q5T4P9	P80217
PDB IDs		3AA1
Enriched GO Terms of Interacting Partners?
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