PLEKHO1 and COL8A2

Data Source:
BioGRID (two hybrid)

		PLEKHO1	COL8A2
Description		pleckstrin homology domain containing O1	collagen type VIII alpha 2 chain
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Ruffle Membrane Muscle Cell Projection Membrane	Extracellular Region Collagen Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix
	Molecular Function	Protein Binding	Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength Protein-macromolecule Adaptor Activity
	Biological Process	Myoblast Fusion Regulation Of Cell Shape Myoblast Migration Lamellipodium Morphogenesis	Angiogenesis Extracellular Matrix Organization Camera-type Eye Morphogenesis Epithelial Cell Proliferation Cell-cell Adhesion
Pathways			Collagen degradation Collagen degradation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Collagen chain trimerization
Drugs
Diseases			Posterior polymorphous corneal dystrophy (PPCD) Fuchs corneal dystrophy (FECD); Fuchs endothelial corneal dystrophy
GWAS		Bipolar disorder ( 31043756) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)	Central corneal thickness ( 32528159 29760442) Corneal structure ( 23291589) Early spontaneous preterm birth ( 31194736) Intraocular pressure ( 29617998 29785010 31959993)
Interacting Genes		32 interacting genes: ADAM33 AKT1 AKT2 BNIP2 BRICD5 C10orf88 C4orf3 CEP19 COL8A2 CSNK2A1 CYP4F2 DNAJB1 FLNB IFI35 LRP10 MMD NAPB PSMC5 RPS20 SMAD5 SMURF1 THSD7B TMEM218 TNF TRAF3IP3 TRAF6 TRAM1L1 TSPAN33 TSPO2 USP7 VAMP3 ZFPL1	18 interacting genes: ARL13B ATP6V0E1 BSND COL8A1 CREB3L1 CYB5R3 DARS2 FAM209A FNDC9 GPR152 GPX8 LMNA MUC1 PEX12 PLEKHO1 SGTA TFAM TMX2
Entrez ID		51177	1296
HPRD ID		12217	08347
Ensembl ID		ENSG00000023902	ENSG00000171812
Uniprot IDs		Q53GL0 Q5T4P9	E9PP49 P25067
PDB IDs		3AA1
Enriched GO Terms of Interacting Partners?
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