IFI35 and CYTH3

Data Source:
BioGRID (two hybrid)

		IFI35	CYTH3
Description		interferon induced protein 35	cytohesin 3
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Cytosol Membrane	Golgi Membrane Ruffle Nucleoplasm Cytosol Plasma Membrane Adherens Junction Bicellular Tight Junction Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
	Molecular Function	Protein Binding Identical Protein Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding
	Biological Process	Macrophage Activation Involved In Immune Response Negative Regulation Of Cell Population Proliferation Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Innate Immune Response Positive Regulation Of Inflammatory Response Type I Interferon Signaling Pathway Negative Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of NIK/NF-kappaB Signaling	Regulation Of ARF Protein Signal Transduction Positive Regulation Of Cell Adhesion Golgi Vesicle Transport Regulation Of Catalytic Activity Establishment Of Epithelial Cell Polarity
Pathways		Interferon alpha/beta signaling	Intra-Golgi traffic
Drugs			Inositol 1,3,4,5-Tetrakisphosphate Inositol-(1,3,4,5,6)-Pentakisphosphate
Diseases
GWAS		Coronary artery disease ( 29212778)	Asthma ( 27611488) Body mass index ( 26426971) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321)
Interacting Genes		12 interacting genes: BATF BCAS2 CLEC4G CYTH3 EML2 FHL2 KDM1A MAPK1 NMI PLEKHO1 TRIM55 TRIM63	12 interacting genes: ARFIP2 CALCOCO1 CCDC120 CNKSR1 CYTIP FRMD4B IFI35 INAVA IPCEF1 PIK3CA SYCE1 TAMALIN
Entrez ID		3430	9265
HPRD ID		02844	05469
Ensembl ID		ENSG00000068079	ENSG00000008256
Uniprot IDs		P80217	O43739
PDB IDs			4KAX 6U3E 6U3G
Enriched GO Terms of Interacting Partners?
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