DCTN4 and ATP7B

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (two hybrid, in vivo)

		DCTN4	ATP7B
Description		dynactin subunit 4	ATPase copper transporting beta
Image		No pdb structure
GO Annotations	Cellular Component	Kinetochore Spindle Pole Stress Fiber Nucleus Cytoplasm Centrosome Cytosol Cytoplasmic Dynein Complex Dynactin Complex Focal Adhesion Cell Cortex Sarcomere	Golgi Membrane Mitochondrion Late Endosome Golgi Apparatus Trans-Golgi Network Integral Component Of Plasma Membrane Membrane Basolateral Plasma Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Protein N-terminus Binding	Copper Ion Transmembrane Transporter Activity Copper Ion Binding Protein Binding ATP Binding P-type Divalent Copper Transporter Activity
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II	Copper Ion Transport Cellular Copper Ion Homeostasis Copper Ion Import Ion Transmembrane Transport Response To Copper Ion Sequestering Of Calcium Ion Copper Ion Export Inorganic Cation Transmembrane Transport
Pathways		MHC class II antigen presentation HSP90 chaperone cycle for steroid hormone receptors (SHR) COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic	Ion transport by P-type ATPases
Drugs
Diseases			Wilson disease; Hepatolenticular degeneration
GWAS		Cholangiocarcinoma in primary sclerosing cholangitis ( 28779025) Crohn's disease ( 28067908) Dimensional psychopathology (Arousal) ( 29496196) Inflammatory bowel disease ( 28067908) Lung adenocarcinoma ( 28604730)	Clostridium difficile infection in multiple myeloma ( 29594489) Mean spheric corpuscular volume ( 32888494) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		8 interacting genes: ACTR10 ACTR1A ATP7B CALCOCO2 GOLGA2 HMG20A MTUS2 PNMA1	4 interacting genes: ATOX1 DCTN4 HP ZBTB16
Entrez ID		51164	540
HPRD ID		13126	06050
Ensembl ID		ENSG00000132912	ENSG00000123191
Uniprot IDs		A0A0S2Z5D4 Q9NSJ5 Q9UJW0	A0A024RDX3 A0A669KB88 B7ZLR3 B7ZLR4 E7ET55 P35670
PDB IDs			2ARF 2EW9 2KOY 2LQB 2N7Y 2ROP 6A71 6A72
Enriched GO Terms of Interacting Partners?
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