ATP7B and HP

Data Source:
BioGRID (two hybrid)

		ATP7B	HP
Description		ATPase copper transporting beta	haptoglobin
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GO Annotations	Cellular Component	Golgi Membrane Mitochondrion Late Endosome Golgi Apparatus Trans-Golgi Network Integral Component Of Plasma Membrane Membrane Basolateral Plasma Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm	Extracellular Region Extracellular Space Haptoglobin-hemoglobin Complex Specific Granule Lumen Extracellular Exosome Endocytic Vesicle Lumen Blood Microparticle Tertiary Granule Lumen
	Molecular Function	Copper Ion Transmembrane Transporter Activity Copper Ion Binding Protein Binding ATP Binding P-type Divalent Copper Transporter Activity	Serine-type Endopeptidase Activity Protein Binding Antioxidant Activity Hemoglobin Binding
	Biological Process	Copper Ion Transport Cellular Copper Ion Homeostasis Copper Ion Import Ion Transmembrane Transport Response To Copper Ion Sequestering Of Calcium Ion Copper Ion Export Inorganic Cation Transmembrane Transport	Acute Inflammatory Response Receptor-mediated Endocytosis Defense Response Acute-phase Response Positive Regulation Of Cell Death Zymogen Activation Response To Hydrogen Peroxide Defense Response To Bacterium Neutrophil Degranulation Negative Regulation Of Oxidoreductase Activity Cellular Oxidant Detoxification Negative Regulation Of Hydrogen Peroxide Catabolic Process
Pathways		Ion transport by P-type ATPases	Scavenging of heme from plasma Neutrophil degranulation
Drugs			Zinc chloride Zinc sulfate, unspecified form
Diseases		Wilson disease; Hepatolenticular degeneration
GWAS		Clostridium difficile infection in multiple myeloma ( 29594489) Mean spheric corpuscular volume ( 32888494) Waist circumference adjusted for body mass index ( 28552196)	Blood protein levels ( 29875488 28240269) Cholesterol, total ( 25961943 20686565) Haptoglobin levels ( 22403646) Hemoglobin levels ( 32327693) LDL cholesterol ( 25961943 20686565) Low density lipoprotein cholesterol levels ( 29403010) Metabolite levels ( 22916037) Metabolite levels (small molecules and protein measures) ( 27005778) Morning person ( 30696823) Parental lifespan ( 30642433) Plasma haptoglobin levels in type 2 diabetes ( 29572449) Total cholesterol levels ( 29403010) Urinary haptoglobin levels in type 2 diabetes ( 29572449)
Interacting Genes		4 interacting genes: ATOX1 DCTN4 HP ZBTB16	21 interacting genes: ADAMTS4 APOA1 ATP7B C1RL CD163 CD22 GADD45G GRB2 HBB ITGAM ITGB2 LAMC3 MVP RBBP6 RPL11 SMAD3 TBL1X TGM2 TP63 VKORC1 WASL
Entrez ID		540	3240
HPRD ID		06050	00772
Ensembl ID		ENSG00000123191	ENSG00000257017
Uniprot IDs		A0A024RDX3 A0A669KB88 B7ZLR3 B7ZLR4 E7ET55 P35670	A0A0C4DGL8 P00738 Q6PEJ8
PDB IDs		2ARF 2EW9 2KOY 2LQB 2N7Y 2ROP 6A71 6A72	4WJG 4X0L 5HU6 6TB2
Enriched GO Terms of Interacting Partners?
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