DCTN4 and ACTR1A

Data Source:
HPRD (in vivo, in vitro)

		DCTN4	ACTR1A
Description		dynactin subunit 4	actin related protein 1A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Kinetochore Spindle Pole Stress Fiber Nucleus Cytoplasm Centrosome Cytosol Cytoplasmic Dynein Complex Dynactin Complex Focal Adhesion Cell Cortex Sarcomere	Manchette Cytoplasm Centrosome Centriole Cytosol Dynactin Complex Microtubule Associated Complex Microtubule Cytoskeleton COPI-coated Vesicle Extracellular Exosome Cell Cortex Region
	Molecular Function	Protein Binding Protein N-terminus Binding	Protein Binding ATP Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II	G2/M Transition Of Mitotic Cell Cycle Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Spermatogenesis Regulation Of G2/M Transition Of Mitotic Cell Cycle Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Ciliary Basal Body-plasma Membrane Docking
Pathways		MHC class II antigen presentation HSP90 chaperone cycle for steroid hormone receptors (SHR) COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic	MHC class II antigen presentation Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic AURKA Activation by TPX2
Drugs
Diseases
GWAS		Cholangiocarcinoma in primary sclerosing cholangitis ( 28779025) Crohn's disease ( 28067908) Dimensional psychopathology (Arousal) ( 29496196) Inflammatory bowel disease ( 28067908) Lung adenocarcinoma ( 28604730)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Prostate cancer ( 23535732) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		8 interacting genes: ACTR10 ACTR1A ATP7B CALCOCO2 GOLGA2 HMG20A MTUS2 PNMA1	5 interacting genes: DCTN1 DCTN4 NUMA1 SPTBN1 SPTBN2
Entrez ID		51164	10121
HPRD ID		13126	05507
Ensembl ID		ENSG00000132912	ENSG00000138107
Uniprot IDs		A0A0S2Z5D4 Q9NSJ5 Q9UJW0	A0A384NQ21 P61163
PDB IDs
Enriched GO Terms of Interacting Partners?
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