PCBD1 and PAH

Data Source:
BioGRID (two hybrid)

		PCBD1	PAH
Description		pterin-4 alpha-carbinolamine dehydratase 1	phenylalanine hydroxylase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Extracellular Exosome	Cytosol
	Molecular Function	Transcription Coactivator Activity Phenylalanine 4-monooxygenase Activity Protein Binding 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Identical Protein Binding	Phenylalanine 4-monooxygenase Activity Iron Ion Binding
	Biological Process	L-phenylalanine Catabolic Process Tetrahydrobiopterin Biosynthetic Process Regulation Of Protein Binding Positive Regulation Of Transcription, DNA-templated	L-phenylalanine Catabolic Process Tyrosine Biosynthetic Process Cellular Amino Acid Biosynthetic Process Neurotransmitter Biosynthetic Process Catecholamine Biosynthetic Process
Pathways		Phenylalanine metabolism	Phenylketonuria Phenylalanine metabolism
Drugs		L-erythro-7,8-dihydrobiopterin	Phenylalanine Sapropterin Norepinephrine Quinonoid 7,8-Tetrahydrobiopterin beta-2-Thienyl-L-alanine L-erythro-7,8-dihydrobiopterin D-norleucine Droxidopa
Diseases		Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient	Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient
GWAS		Blood protein levels ( 30072576) Chronotype ( 30696823) Immature fraction of reticulocytes ( 27863252) Microalbuminuria ( 26631737) Obesity-related traits ( 23251661)	Amino acid levels ( 26068415) Bisphosphonate-associated atypical femoral fracture ( 31006051) Blood metabolite levels ( 24816252) Metabolite levels (small molecules and protein measures) ( 27005778) Plasma free amino acid levels ( 30659259) Plasma free amino acid levels (adjusted for one other PFAA) ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271)
Interacting Genes		54 interacting genes: ACIN1 APP BRD7 CACNA1C CALCOCO1 CDK5RAP2 CEBPZ DENND4A DIP2C DVL2 DYRK1B EHMT1 FXR2 GORASP2 GTF3C3 HES4 HNF1A HNF1B HNF4A KANK2 KLF13 LNX1 MIS18BP1 NFKB1 NIF3L1 NTAQ1 NUDT18 PAH PAPOLG PCBD2 PICK1 POLR3A PSMA1 RBL2 RPS24 SAP30 SCMH1 SDCBP SMARCD1 SOWAHC SUPT5H TFF3 TIMELESS TRIM5 WWP1 ZBTB25 ZNF195 ZNF202 ZNF23 ZNF263 ZNF451 ZNF567 ZNF688 ZNF714	3 interacting genes: PCBD1 QDPR RPS24
Entrez ID		5092	5053
HPRD ID		00523	08943
Ensembl ID		ENSG00000166228	ENSG00000171759
Uniprot IDs		P61457	A0A024RBG4 P00439
PDB IDs			1DMW 1J8T 1J8U 1KW0 1LRM 1MMK 1MMT 1PAH 1TDW 1TG2 2PAH 3PAH 4ANP 4PAH 5FII 5PAH 6HPO 6HYC 6N1K 6PAH
Enriched GO Terms of Interacting Partners?
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