PCBD1 and DENND4A

Data Source:
BioGRID (two hybrid)

		PCBD1	DENND4A
Description		pterin-4 alpha-carbinolamine dehydratase 1	DENN domain containing 4A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Extracellular Exosome	Nucleus Cytosol Cytoplasmic Vesicle
	Molecular Function	Transcription Coactivator Activity Phenylalanine 4-monooxygenase Activity Protein Binding 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Identical Protein Binding	DNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	L-phenylalanine Catabolic Process Tetrahydrobiopterin Biosynthetic Process Regulation Of Protein Binding Positive Regulation Of Transcription, DNA-templated	Regulation Of Transcription, DNA-templated Regulation Of Rab Protein Signal Transduction Regulation Of Catalytic Activity
Pathways		Phenylalanine metabolism	RAB GEFs exchange GTP for GDP on RABs
Drugs		L-erythro-7,8-dihydrobiopterin
Diseases		Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient
GWAS		Blood protein levels ( 30072576) Chronotype ( 30696823) Immature fraction of reticulocytes ( 27863252) Microalbuminuria ( 26631737) Obesity-related traits ( 23251661)	Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Estimated glomerular filtration rate ( 31152163) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) High light scatter reticulocyte percentage of red cells ( 32888494) Intelligence (MTAG) ( 29326435) Logical memory (delayed recall) in normal cognition ( 29274321) Mean corpuscular hemoglobin ( 29403010 20139978 27863252) Mean corpuscular hemoglobin concentration ( 29403010 27863252) Mean corpuscular volume ( 29403010 27863252) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Red blood cell count ( 27863252) Red blood cell traits ( 23222517) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		54 interacting genes: ACIN1 APP BRD7 CACNA1C CALCOCO1 CDK5RAP2 CEBPZ DENND4A DIP2C DVL2 DYRK1B EHMT1 FXR2 GORASP2 GTF3C3 HES4 HNF1A HNF1B HNF4A KANK2 KLF13 LNX1 MIS18BP1 NFKB1 NIF3L1 NTAQ1 NUDT18 PAH PAPOLG PCBD2 PICK1 POLR3A PSMA1 RBL2 RPS24 SAP30 SCMH1 SDCBP SMARCD1 SOWAHC SUPT5H TFF3 TIMELESS TRIM5 WWP1 ZBTB25 ZNF195 ZNF202 ZNF23 ZNF263 ZNF451 ZNF567 ZNF688 ZNF714	7 interacting genes: C1QTNF9 CEBPE CLK1 PCBD1 SERTAD1 TLX3 YWHAG
Entrez ID		5092	10260
HPRD ID		00523	02662
Ensembl ID		ENSG00000166228	ENSG00000174485
Uniprot IDs		P61457	Q05C90 Q7Z401
PDB IDs
Enriched GO Terms of Interacting Partners?
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