PCBD1 and KLF13

Data Source:
BioGRID (two hybrid)

		PCBD1	KLF13
Description		pterin-4 alpha-carbinolamine dehydratase 1	Kruppel like factor 13
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Extracellular Exosome	Chromatin Nucleus
	Molecular Function	Transcription Coactivator Activity Phenylalanine 4-monooxygenase Activity Protein Binding 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Identical Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	L-phenylalanine Catabolic Process Tetrahydrobiopterin Biosynthetic Process Regulation Of Protein Binding Positive Regulation Of Transcription, DNA-templated	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Phenylalanine metabolism
Drugs		L-erythro-7,8-dihydrobiopterin
Diseases		Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient
GWAS		Blood protein levels ( 30072576) Chronotype ( 30696823) Immature fraction of reticulocytes ( 27863252) Microalbuminuria ( 26631737) Obesity-related traits ( 23251661)	Brain volume in infants (intracranial brain volume) ( 28763065) Deep white matter hyperintensities ( 32517579) Eosinophilic esophagitis ( 25017104) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 29403010 32888494) Psoriasis ( 28537254) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Triglyceride levels ( 32203549) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
Interacting Genes		54 interacting genes: ACIN1 APP BRD7 CACNA1C CALCOCO1 CDK5RAP2 CEBPZ DENND4A DIP2C DVL2 DYRK1B EHMT1 FXR2 GORASP2 GTF3C3 HES4 HNF1A HNF1B HNF4A KANK2 KLF13 LNX1 MIS18BP1 NFKB1 NIF3L1 NTAQ1 NUDT18 PAH PAPOLG PCBD2 PICK1 POLR3A PSMA1 RBL2 RPS24 SAP30 SCMH1 SDCBP SMARCD1 SOWAHC SUPT5H TFF3 TIMELESS TRIM5 WWP1 ZBTB25 ZNF195 ZNF202 ZNF23 ZNF263 ZNF451 ZNF567 ZNF688 ZNF714	9 interacting genes: CREBBP EP300 KAT2B PCBD1 PRPF4B SERPINH1 SIN3A SREBF1 SREBF2
Entrez ID		5092	51621
HPRD ID		00523	05620
Ensembl ID		ENSG00000166228	ENSG00000169926
Uniprot IDs		P61457	Q9Y2Y9 X5DNR2
PDB IDs
Enriched GO Terms of Interacting Partners?
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