PAH and QDPR

Data Source:
BioGRID (two hybrid)

		PAH	QDPR
Description		phenylalanine hydroxylase	quinoid dihydropteridine reductase
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GO Annotations	Cellular Component	Cytosol	Cytoplasm Cytosol Neuron Projection Extracellular Exosome
	Molecular Function	Phenylalanine 4-monooxygenase Activity Iron Ion Binding	6,7-dihydropteridine Reductase Activity Electron Transfer Activity Identical Protein Binding NADPH Binding NADH Binding
	Biological Process	L-phenylalanine Catabolic Process Tyrosine Biosynthetic Process Cellular Amino Acid Biosynthetic Process Neurotransmitter Biosynthetic Process Catecholamine Biosynthetic Process	Liver Development Cellular Amino Acid Metabolic Process L-phenylalanine Catabolic Process Tetrahydrobiopterin Biosynthetic Process Response To Aluminum Ion Response To Lead Ion Electron Transport Chain Response To Glucagon Cellular Response To Drug Dihydrobiopterin Metabolic Process
Pathways		Phenylketonuria Phenylalanine metabolism	Phenylalanine metabolism
Drugs		Phenylalanine Sapropterin Norepinephrine Quinonoid 7,8-Tetrahydrobiopterin beta-2-Thienyl-L-alanine L-erythro-7,8-dihydrobiopterin D-norleucine Droxidopa	NADH 2-(N-morpholino)ethanesulfonic acid
Diseases		Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient	Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient
GWAS		Amino acid levels ( 26068415) Bisphosphonate-associated atypical femoral fracture ( 31006051) Blood metabolite levels ( 24816252) Metabolite levels (small molecules and protein measures) ( 27005778) Plasma free amino acid levels ( 30659259) Plasma free amino acid levels (adjusted for one other PFAA) ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271)	Blood protein levels ( 30072576 29875488)
Interacting Genes		3 interacting genes: PCBD1 QDPR RPS24	5 interacting genes: ANKRD13A CASP8 KRAS PAH RXFP4
Entrez ID		5053	5860
HPRD ID		08943	02025
Ensembl ID		ENSG00000171759	ENSG00000151552
Uniprot IDs		A0A024RBG4 P00439	A0A140VKA9 P09417
PDB IDs		1DMW 1J8T 1J8U 1KW0 1LRM 1MMK 1MMT 1PAH 1TDW 1TG2 2PAH 3PAH 4ANP 4PAH 5FII 5PAH 6HPO 6HYC 6N1K 6PAH	1HDR
Enriched GO Terms of Interacting Partners?
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