CKMT2 and NRF1

Data Source:
BioGRID (two hybrid)

		CKMT2	NRF1
Description		creatine kinase, mitochondrial 2	nuclear respiratory factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane	Nucleus Nucleoplasm Cytosol Extracellular Exosome
	Molecular Function	Creatine Kinase Activity Protein Binding ATP Binding Kinase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Protein Homodimerization Activity
	Biological Process	Creatine Metabolic Process Muscle Contraction Phosphorylation Phosphocreatine Biosynthetic Process	Regulation Of Transcription By RNA Polymerase II Mitochondrion Organization Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Creatine metabolism	PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Transcriptional activation of mitochondrial biogenesis
Drugs		Creatine Phosphocreatine
Diseases
GWAS			Bipolar disorder ( 31043756) Obesity-related traits ( 23251661) Platelet count ( 27863252) Plateletcrit ( 27863252) Red cell distribution width ( 28957414) Response to antidepressants and depression ( 27622933)
Interacting Genes		10 interacting genes: ABHD6 CETN3 ELN KLHL42 LRIF1 NRF1 OLFML3 P4HA3 TMED9 UNC119	48 interacting genes: AGR2 BBS2 BICRAL BRWD1 C10orf55 C3orf36 CKMT2 COL10A1 CSNK2A1 CSNK2B DYNLL1 ESM1 FHL2 HHIPL1 HIVEP1 KHDC4 KLF15 KPNA5 KRT83 L3MBTL2 L3MBTL3 LHX3 LHX4 LHX6 LMO4 MAFF MVP NDUFAB1 PANX2 PARP1 PLXDC1 POGZ PPARGC1A PPRC1 SIAH2 SLC22A18AS SP2 SP4 SPSB2 SRARP TESMIN TEX43 TOLLIP TRAF2 TRIM35 VEZF1 YPEL3 ZMYM6
Entrez ID		1160	4899
HPRD ID		00425	02930
Ensembl ID		ENSG00000131730	ENSG00000106459
Uniprot IDs		A0A024RAK5 P17540	A0A024R770 A0A024R774 Q16656
PDB IDs		4Z9M
Enriched GO Terms of Interacting Partners?
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