TCL1A and H2AW

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TCL1A	H2AW
Description		TCL1 family AKT coactivator A	H2A.W histone
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Endoplasmic Reticulum Cytosol Protein-containing Complex	Nucleosome Nucleus Extracellular Exosome
	Molecular Function	Protein Binding Protein Kinase Binding Identical Protein Binding Protein Serine/threonine Kinase Activator Activity	DNA Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	Multicellular Organism Development Positive Regulation Of Cell Population Proliferation Positive Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Apoptotic Process Cellular Response To Tumor Necrosis Factor Positive Regulation Of Protein Serine/threonine Kinase Activity	Nucleosome Disassembly Chromatin Silencing UV-damage Excision Repair
Pathways			HDACs deacetylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines UCH proteinases Ub-specific processing proteases Metalloprotease DUBs HCMV Early Events HCMV Late Events
Drugs
Diseases
GWAS		Adverse response to aromatase inhibitors ( 20876420) Mosaic loss of chromosome Y ( 27064253) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Plateletcrit ( 32888494) Refractive error ( 32231278)
Interacting Genes		38 interacting genes: AKT1 AKT2 AKT3 ATM CADPS CALCOCO2 CARD9 CASP8AP2 CCDC13 CEP55 DDIT4L DNMT3A FLACC1 GOLGA2 H2AW INCA1 LNX1 LNX2 LSM3 NFKBIA NFKBID NIF3L1 NTAQ1 PPP1R13B PRTFDC1 REL TAX1BP1 TCF4 TEPSIN TNKS TP53BP2 TRAF1 TRAF2 TRMT61A TTC33 TXLNA TXLNB WDR47	6 interacting genes: CBX5 DNTTIP2 HSF2BP KRTAP10-3 RPS6KA5 TCL1A
Entrez ID		8115	92815
HPRD ID		01744	13660
Ensembl ID		ENSG00000100721	ENSG00000181218
Uniprot IDs		A0A024R6G5 P56279	Q7L7L0
PDB IDs		1JSG
Enriched GO Terms of Interacting Partners?
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