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UBE2D1 and EPS15
Data Source:
BioGRID
(enzymatic study)
UBE2D1
EPS15
Description
ubiquitin conjugating enzyme E2 D1
epidermal growth factor receptor pathway substrate 15
Image
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Protein-containing Complex
Cytoplasm
Cytosol
Plasma Membrane
Clathrin-coated Pit
Basal Plasma Membrane
Membrane
Aggresome
Apical Plasma Membrane
Clathrin Coat Of Coated Pit
Early Endosome Membrane
Intracellular Membrane-bounded Organelle
Postsynapse
Glutamatergic Synapse
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Ubiquitin Protein Ligase Binding
Ubiquitin Protein Ligase Activity
Ubiquitin Conjugating Enzyme Activity
Calcium Ion Binding
Protein Binding
SH3 Domain Binding
Polyubiquitin Modification-dependent Protein Binding
Cadherin Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Protein Polyubiquitination
MyD88-independent Toll-like Receptor Signaling Pathway
Ubiquitin-dependent Protein Catabolic Process
Protein Targeting To Peroxisome
Protein Ubiquitination
Protein Deubiquitination
BMP Signaling Pathway
Anaphase-promoting Complex-dependent Catabolic Process
Positive Regulation Of Protein Ubiquitination
TRIF-dependent Toll-like Receptor Signaling Pathway
Protein K48-linked Ubiquitination
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Protein Polyubiquitination
Positive Regulation Of Receptor Recycling
Golgi To Endosome Transport
Endocytosis
Vesicle Organization
Endosomal Transport
Receptor-mediated Endocytosis Of Virus By Host Cell
Endocytic Recycling
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Cell Population Proliferation
Viral Entry Into Host Cell
Clathrin Coat Assembly
Membrane Organization
Postsynaptic Neurotransmitter Receptor Internalization
Pathways
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Inactivation of APC/C via direct inhibition of the APC/C complex
TICAM1, RIP1-mediated IKK complex recruitment
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Signaling by BMP
Downstream TCR signaling
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
FCERI mediated NF-kB activation
CLEC7A (Dectin-1) signaling
Ovarian tumor domain proteases
CDK-mediated phosphorylation and removal of Cdc6
Transcriptional Regulation by VENTX
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
E3 ubiquitin ligases ubiquitinate target proteins
Neddylation
Peroxisomal protein import
Negative regulators of DDX58/IFIH1 signaling
IKK complex recruitment mediated by RIP1
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Antigen processing: Ubiquitination & Proteasome degradation
EGFR downregulation
Negative regulation of MET activity
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
InlB-mediated entry of Listeria monocytogenes into host cell
Drugs
Diseases
GWAS
Brain imaging (
20100581
)
Crohn's disease (
21102463
)
Blood urea nitrogen levels (
31152163
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
IgE grass sensitization (
22036096
)
PR interval (
30046033
32439900
)
Interacting Genes
239 interacting genes:
AMFR
ANAPC11
ANXA1
ANXA7
AREL1
ARIH1
ARIH2
ARRDC3
ASB2
ASB4
ASB9
BABAM2
BARD1
BFAR
BIK
BIRC2
BIRC3
BIRC6
BIRC7
BIRC8
BRCA1
BRCC3
BRMS1
C7orf25
CADPS2
CBL
CBLC
CDK7
CDKN1A
CHFR
CNOT4
COP1
CRBN
CREBBP
CRYAB
CTNNB1
CUL2
CUL3
DDX58
DTL
DTX1
DTX2
DTX3
DTX3L
DYRK2
DZIP3
EP300
EPS15
F12
FAF2
FBXL17
FBXL2
FBXO2
FBXO7
FOS
FZR1
GADD45A
GSK3B
H3C1
H4C1
HDAC6
HECW1
HERC2
HERC3
HERC5
HIF1A
HSD17B10
HUWE1
ITCH
KAT2B
KCTD17
KDM2B
KLHL13
KLHL2
KLHL9
LNPK
LRR1
LRSAM1
LTN1
MAP3K1
MARCHF1
MARCHF2
MARCHF4
MARCHF5
MARCHF7
MARCHF8
MDM2
MDM4
MEOX2
MGRN1
MIB1
MID1
MID2
MKNK1
MKRN1
MKRN2
MKRN3
MUL1
NBN
NEDD4
NEDD4L
NEURL1
NFKBIA
NHLRC1
NONO
NQO1
NR1H2
OBI1
OTUB1
OTULIN
PELI1
PER2
PJA2
POLL
POLM
PRKN
RABGEF1
RAG1
RBCK1
RBX1
RCHY1
RELA
RFFL
RFWD3
RING1
RLIM
RMND5A
RNF10
RNF103
RNF11
RNF111
RNF114
RNF115
RNF122
RNF123
RNF125
RNF126
RNF128
RNF13
RNF130
RNF14
RNF144A
RNF150
RNF165
RNF166
RNF167
RNF168
RNF181
RNF182
RNF185
RNF2
RNF216
RNF25
RNF26
RNF31
RNF38
RNF4
RNF43
RNF5
RNF6
RNF7
RNF8
RSAD2
SH3RF1
SHPRH
SIAH1
SIAH2
SIRT6
SIVA1
SKP1
SMURF1
SMURF2
SPOP
STAM2
STUB1
SUFU
TAF1D
TBL1X
TMEM129
TNFAIP3
TNNT1
TOM1
TOPORS
TP53
TRAF2
TRAF4
TRAF6
TRAF7
TRAIP
TRIM10
TRIM17
TRIM2
TRIM21
TRIM23
TRIM25
TRIM26
TRIM27
TRIM28
TRIM3
TRIM31
TRIM32
TRIM35
TRIM37
TRIM38
TRIM39
TRIM43
TRIM45
TRIM5
TRIM50
TRIM54
TRIM55
TRIM62
TRIM63
TRIM69
TRIM7
TRIM8
TRIP12
TSC22D1
UBA1
UBA6
UBASH3B
UBC
UBE3A
UBE3C
UBE4A
UBOX5
UBTD1
UFM1
UHRF1
UHRF2
UVSSA
VHL
WWP1
WWP2
XIAP
ZNF598
ZNRF1
ZNRF2
ZNRF4
49 interacting genes:
AGFG1
AGFG2
AP1G1
AP2A1
AP2A2
CLINT1
CORO7
CRK
DNM1
DNM2
EGFR
ELF3
EPN1
EPN2
FCHO1
FCHO2
GRB2
HGS
ITSN1
LAPTM5
MAPK14
MOB4
MTNR1A
NAGPA
NEDD4
NUMB
NUMBL
PRKN
REPS2
RNF11
SCAMP1
SGIP1
SNAP91
SPART
SPOPL
STAM2
STAMBP
STON2
SYNJ1
TFAP2A
UBB
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2H
UBQLN1
USP8
Entrez ID
7321
2060
HPRD ID
04267
08968
Ensembl ID
ENSG00000072401
ENSG00000085832
Uniprot IDs
A0A024QZJ2
A0A087WW00
P51668
B7Z240
P42566
PDB IDs
2C4P
2YHO
3OJ4
3PTF
4AP4
4QPL
5FER
5TUT
6D4P
1C07
1EH2
1F8H
1FF1
2IV9
2JXC
4RH5
4RH9
4RHG
4S0G
5AWT
5AWU
5JP2
Enriched GO Terms of Interacting Partners
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