PTPN1 and CRK

Data Source:
BioGRID (pull down)

		PTPN1	CRK
Description		protein tyrosine phosphatase non-receptor type 1	CRK proto-oncogene, adaptor protein
Image
GO Annotations	Cellular Component	Mitochondrial Matrix Early Endosome Endoplasmic Reticulum Cytosol Plasma Membrane Mitochondrial Crista Protein-containing Complex Sorting Endosome Cytoplasmic Side Of Endoplasmic Reticulum Membrane	Nucleus Cytoplasm Cytosol Plasma Membrane Actin Cytoskeleton Membrane Protein-containing Complex Membrane Raft Extracellular Exosome
	Molecular Function	RNA Binding Protein Tyrosine Phosphatase Activity Insulin Receptor Binding Protein Binding Zinc Ion Binding Enzyme Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding Cadherin Binding Ephrin Receptor Binding Protein Phosphatase 2A Binding	Phosphotyrosine Residue Binding Insulin-like Growth Factor Receptor Binding Protein Binding Cytoskeletal Protein Binding SH3 Domain Binding Kinase Binding Signaling Receptor Complex Adaptor Activity Ubiquitin Protein Ligase Binding Signaling Adaptor Activity SH2 Domain Binding Protein Self-association Protein Phosphorylated Amino Acid Binding Ephrin Receptor Binding Scaffold Protein Binding Protein Tyrosine Kinase Binding
	Biological Process	Protein Dephosphorylation Activation Of JUN Kinase Activity Insulin Receptor Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Endocytosis Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Actin Cytoskeleton Reorganization Regulation Of Intracellular Protein Transport Cellular Response To Unfolded Protein Peptidyl-tyrosine Dephosphorylation Platelet-derived Growth Factor Receptor-beta Signaling Pathway IRE1-mediated Unfolded Protein Response Negative Regulation Of MAP Kinase Activity Negative Regulation Of Insulin Receptor Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of IRE1-mediated Unfolded Protein Response Negative Regulation Of PERK-mediated Unfolded Protein Response Peptidyl-tyrosine Dephosphorylation Involved In Inactivation Of Protein Kinase Activity Positive Regulation Of Receptor Catabolic Process	Activation Of MAPKK Activity Neuron Migration Response To Yeast Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process Regulation Of Cell Shape Regulation Of Signal Transduction Positive Regulation Of Smooth Muscle Cell Migration Dendrite Development Cytokine-mediated Signaling Pathway Hippocampus Development Cerebral Cortex Development Establishment Of Cell Polarity Actin Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Rac Protein Signal Transduction Helper T Cell Diapedesis Response To Hepatocyte Growth Factor Reelin-mediated Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Response To Hydrogen Peroxide Regulation Of GTPase Activity Regulation Of Protein Binding Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Dendrite Development Cell Chemotaxis Negative Regulation Of Wound Healing Response To Cholecystokinin Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To Nitric Oxide Activation Of GTPase Activity Cerebellar Neuron Development Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Intracellular Signal Transduction Cellular Response To Nerve Growth Factor Stimulus Cellular Response To Insulin-like Growth Factor Stimulus Cellular Response To Endothelin Negative Regulation Of Cell Motility Regulation Of T Cell Migration
Pathways		Integrin signaling Negative regulation of MET activity Regulation of IFNG signaling PTK6 Down-Regulation MECP2 regulates neuronal receptors and channels Regulation of IFNA signaling Growth hormone receptor signaling Growth hormone receptor signaling	ARMS-mediated activation ARMS-mediated activation Downstream signal transduction Regulation of actin dynamics for phagocytic cup formation p130Cas linkage to MAPK signaling for integrins VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases MET activates RAP1 and RAC1 MET receptor recycling Regulation of signaling by CBL FCGR3A-mediated phagocytosis
Drugs		3-(Oxalyl-Amino)-Naphthalene-2-Carboxylic Acid 2-{[4-(2-Acetylamino-2-pentylcarbamoyl-ethyl)-naphthalen-1-YL]-oxalyl-amino}-benzoic acid 5-(2-Fluoro-5-{(1E)-3-[3-hydroxy-2-(methoxycarbonyl)phenoxy]-1-propen-1-yl}phenyl)-1,2-oxazole-3-carboxylic acid 2-(Oxalyl-Amino)-4,7-Dihydro-5h-Thieno[2,3-C]Thiopyran-3-Carboxylic Acid 3-(3,5-Dibromo-4-Hydroxy-Benzoyl)-2-Ethyl-Benzofuran-6-Sulfonic Acid (4-Sulfamoyl-Phenyl)-Amide [[4-(Aminomethyl)Phenyl]Amino]Oxo-Acetic Acid, {4-[(2S)-2-({[(1S)-1-Carboxy-2-phenylethyl]carbamoyl}amino)-3-oxo-3-(pentylamino)propyl]phenoxy}malonic acid Compound 19 3-(4-{2-[2-(2-bromo-acetylamino)-ethyldisulfanyl]-ethylcarbamoyl}-cyclohexylcarbamoyl)-pyrazine-2-carboxylic acid 2-(Oxalyl-Amino)-Benzoic Acid {[2-(1h-1,2,3-Benzotriazol-1-Yl)-2-(3,4-Difluorophenyl)Propane-1,3-Diyl]Bis[4,1-Phenylene(Difluoromethylene)]}Bis(Phosphonic Acid) Novo Nordisk a/S Compound N-(Bromoacetyl)-beta-alanyl-N-(2-{4-[(carboxycarbonyl)amino]phenyl}ethyl)-L-serinamide 7-(1,1-Dioxo-1h-Benzo[D]Isothiazol-3-Yloxymethyl)-2-(Oxalyl-Amino)-4,7-Dihydro-5h-Thieno[2,3-C]Pyran-3-Carboxylic Acid PNU177836 2-(Oxalyl-Amino)-4,7-Dihydro-5h-Thieno[2,3-C]Pyran-3-Carboxylic Acid {[7-(Difluoro-Phosphono-Methyl)-Naphthalen-2-Yl]-Difluoro-Methyl}-Phosphonic Acid 3-(3,5-Dibromo-4-Hydroxy-Benzoyl)-2-Ethyl-Benzofuran-6-Sulfonic Acid [4-(Thiazol-2-Ylsulfamoyl)-Phenyl]-Amide (4S)-5-[[(2S)-1-[[(2S)-1-Amino-3-[4-[difluoro(phosphono)methyl]phenyl]-1-oxopropan-2-yl]amino]-3-[4-[difluoro(phosphono)methyl]phenyl]-1-oxopropan-2-yl]amino]-4-benzamido-5-oxopentanoic acid 4-[[(2S)-1-[[6-[(1-Amino-1-oxo-3-sulfanylpropan-2-yl)amino]-6-oxohexyl]amino]-3-[4-[difluoro(phosphono)methyl]phenyl]-1-oxopropan-2-yl]amino]-3-[[2-[4-[difluoro(phosphono)methyl]phenyl]acetyl]amino]-4-oxobutanoic acid L-cysteic acid 2-(Oxalyl-Amino)-4,5,6,7-Tetrahydro-Thieno[2,3-C]Pyridine-3-Carboxylic Acid 4-Carbamoyl-4-{[6-(Difluoro-Phosphono-Methyl)-Naphthalene-2-Carbonyl]-Amino}-Butyric Acid Compound 5, 2-(Naphthalen-1-Yl-Oxalyl-Amino)-Benzoicacid 6-(Oxalyl-Amino)-1h-Indole-5-Carboxylic Acid 2-[{4-[(2S)-2-{[(Allyloxy)carbonyl]amino}-3-({4-[3-hydroxy-2-(methoxycarbonyl)phenoxy]butyl}amino)-3-oxopropyl]phenyl}(carboxycarbonyl)amino]benzoic acid 3-(3,5-Dibromo-4-Hydroxy-Benzoyl)-2-Ethyl-Benzofuran-6-Sulfonic Acid Dimethylamide [(4-{4-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Butyl}-Phenyl)-Difluoro-Methyl]-Phosphonic Acid {4-[(2s,4e)-2-(1,3-Benzothiazol-2-Yl)-2-(1h-1,2,3-Benzotriazol-1-Yl)-5-Phenylpent-4-Enyl]Phenyl}(Difluoro)Methylphosphonic Acid N-(3-Carboxypropanoyl)-L-phenylalanyl-3-carboxy-O-(carboxymethyl)-N-pentyl-L-tyrosinamide 1-METHYL-3-PHENYL-1H-PYRAZOL-5-YLSULFAMIC ACID ISIS 113715 Trodusquemine Ertiprotafib 4-BROMO-3-(CARBOXYMETHOXY)-5-[3-(CYCLOHEXYLAMINO)PHENYL]THIOPHENE-2-CARBOXYLIC ACID [(3S)-3-(Methylcarbamoyl)-2-{[(2-methyl-2-propanyl)oxy]carbonyl}-1,2,3,4-tetrahydro-7-isoquinolinyl]sulfamic acid 4-BROMO-3-(CARBOXYMETHOXY)-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID 5-(4-CHLORO-5-PHENYL-3-THIENYL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE 4-BROMO-3-(CARBOXYMETHOXY)-5-(4-HYDROXYPHENYL)THIOPHENE-2-CARBOXYLIC ACID [{2-bromo-4-[(2R)-3-oxo-2,3-diphenylpropyl]phenyl}(difluoro)methyl]phosphonic acid 5-[3-(BENZYLAMINO)PHENYL]-4-BROMO-3-(CARBOXYMETHOXY)THIOPHENE-2-CARBOXYLIC ACID 2-[(7-HYDROXY-NAPHTHALEN-1-YL)-OXALYL-AMINO]-BENZOIC ACID 3-(CARBOXYMETHOXY)THIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID 4-PHOSPHONOOXY-PHENYL-METHYL-[4-PHOSPHONOOXY]BENZEN N-ACETYL-L-PHENYLALANYL-4-[DIFLUORO(PHOSPHONO)METHYL]-L-PHENYLALANINAMIDE [(3R)-3-(Methylcarbamoyl)-2-{[(2-methyl-2-propanyl)oxy]carbonyl}-1,2,3,4-tetrahydro-7-isoquinolinyl]sulfamic acid 5-(3-HYDROXYPHENYL)ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDE 5-(3-{3-[3-HYDROXY-2-(METHOXYCARBONYL)PHENOXY]PROPENYL}PHENYL)-4-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLIC ACID ISOTHIAZOLIDINONE ANALOG 4-[3-(dibenzylamino)phenyl]-2,4-dioxobutanoic acid p-Benzoyl-L-phenylalanine 6-(DIFLUORO-PHOSPHONO-METHYL)-NAPHTHALENE-2-CARBOXYLIC ACID (3R)-METHYLCARBAMOYL-7-SULFOAMINO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID BENZYL ESTER 5-(4-METHOXYBIPHENYL-3-YL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE 1,2,5-THIADIAZOLIDIN-3-ONE-1,1-DIOXIDE (4-{(2S)-2-[(tert-butoxycarbonyl)amino]-3-methoxy-3-oxopropyl}phenyl)methaneseleninic acid
Diseases
GWAS		Basophil count ( 32888494) Colorectal cancer ( 30529582 31826910) Colorectal cancer or advanced adenoma ( 30510241) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Intraocular pressure ( 29617998 29785010 31959993 30054594) Lymphocyte percentage of white cells ( 32888494) Thyroid stimulating hormone levels ( 30843173) Vitiligo ( 27723757)	Atrial fibrillation ( 30061737) Granulocyte count ( 27863252) Intraocular pressure ( 30591961) Lymphocyte percentage of white cells ( 32888494 27863252) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Pulse pressure ( 27841878) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systolic blood pressure ( 28135244 27841878 30578418)
Interacting Genes		66 interacting genes: ACTN1 AGR3 AKT1 AQP6 ASS1 BCAR1 BCAS3 BCR CAPN2 CASC3 CASZ1 CAV1 CCL5 CDH13 CDH2 CDK1 CLK1 CLK2 COP1 CRK CSNK2A1 CSNK2A2 CTNNB1 DIRAS3 EGFR ELOVL4 ESR1 FGFR1 GHR GLRX GRB2 GSK3B IGF1R INSR IRS1 JAK2 KLK7 LAT LRATD2 LTK MAPK1 MRC2 NFKBIA NTRK1 NTRK2 NTRK3 PDGFRB PIAS1 PIGP PIN1 RHOBTB2 RRAS2 SNAI1 SRC STAM2 STAT3 STAT5A STAT5B THRSP TIMMDC1 TMEM31 TMEM41A TMEM86B TRPV6 TYK2 VPS45	169 interacting genes: ABL1 ABL2 ANKZF1 ANLN AR ARHGAP17 ARHGAP32 ASAP1 ASAP3 ASCL4 ATF3 ATXN1 AVIL BATF3 BCAR1 BCR BEX5 BUB1 C1orf94 C4orf17 C6orf141 CBL CBLB CBLC CHTF18 CLNK CNDP2 CORO6 CRKL DAB1 DOCK1 DOCK3 DOK1 DOK2 DOK3 DOK4 DOK7 DPPA4 EFS EGFR ELK1 ELK3 EPHA3 EPHB2 EPHB3 EPHB6 EPS15 EPYC ERBB2 ERBB3 ERBB4 ESD EYA3 FASLG FER FGFR1 FLACC1 FLT1 FRS2 FSTL1 FYN GAB1 GABPB2 GAREM1 GRB2 HABP4 HSH2D IFT140 IGF1R IKZF3 INO80E INSR IRS1 IRS2 IRS4 ISL1 KCTD13 KCTD17 KDR KHDRBS1 KIT KLF15 KLHL20 LASP1 LHX8 LNX2 MAGEC3 MAP4K1 MAP4K5 MAPK4 MAPK8 MET MICAL1 MNDA MPG MYLIP MYOZ2 NCK1 NEDD9 NTRK1 NUFIP2 OFCC1 PAFAH1B2 PDGFRA PDGFRB PHC2 PIK3R1 PIK3R2 PIK3R3 PLSCR1 POT1 PPFIBP2 PPP1CA PRKACA PRRC2B PRRG2 PSMC1 PSMC6 PTK2 PTK2B PTPN1 PTPN4 PTPRH PTTG1 PXN RAB2B RAPGEF1 REPS1 RET RIN3 RTCB RYBP SASH1 SAXO1 SEMA4D SEPTIN6 SETD9 SH2D2A SH3BP1 SHB SHC1 SOCS1 SOCS6 SOS1 SPRR2A STAT4 STAT5A STAT5B STRN4 SYN1 TCAP TDG TERF2IP TM4SF19 TP53 TP53BP2 TUBA1C TWIST2 TXK USP53 VAC14 VAV1 WASF1 WDR83 WEE1 XPO1 ZAP70 ZKSCAN7 ZNF557
Entrez ID		5770	1398
HPRD ID		01477	01267
Ensembl ID		ENSG00000196396	ENSG00000167193
Uniprot IDs		A8K3M3 B4DSN5 P18031	A0A0S2Z3K9 A0A0S2Z3Q4 L7RT18 P46108
PDB IDs		1A5Y 1AAX 1BZC 1BZH 1BZJ 1C83 1C84 1C85 1C86 1C87 1C88 1ECV 1EEN 1EEO 1G1F 1G1G 1G1H 1G7F 1G7G 1GFY 1I57 1JF7 1KAK 1KAV 1L8G 1LQF 1NL9 1NNY 1NO6 1NWE 1NWL 1NZ7 1OEM 1OEO 1OES 1OET 1OEU 1OEV 1ONY 1ONZ 1PA1 1PH0 1PTT 1PTU 1PTV 1PTY 1PXH 1PYN 1Q1M 1Q6J 1Q6M 1Q6N 1Q6P 1Q6S 1Q6T 1QXK 1SUG 1T48 1T49 1T4J 1WAX 1XBO 2AZR 2B07 2B4S 2BGD 2BGE 2CM2 2CM3 2CM7 2CM8 2CMA 2CMB 2CMC 2CNE 2CNF 2CNG 2CNH 2CNI 2F6F 2F6T 2F6V 2F6W 2F6Y 2F6Z 2F70 2F71 2FJM 2FJN 2H4G 2H4K 2HB1 2HNP 2HNQ 2NT7 2NTA 2QBP 2QBQ 2QBR 2QBS 2VEU 2VEV 2VEW 2VEX 2VEY 2ZMM 2ZN7 3A5J 3A5K 3CWE 3D9C 3EAX 3EB1 3EU0 3I7Z 3I80 3QKP 3QKQ 3SME 3ZMP 3ZMQ 3ZV2 4BJO 4I8N 4QAH 4QAP 4QBE 4QBW 4Y14 4ZRT 5K9V 5K9W 5KA0 5KA1 5KA2 5KA3 5KA4 5KA7 5KA8 5KA9 5KAA 5KAB 5KAC 5KAD 5QDE 5QDF 5QDG 5QDH 5QDI 5QDJ 5QDK 5QDL 5QDM 5QDN 5QDO 5QDP 5QDQ 5QDR 5QDS 5QDT 5QDU 5QDV 5QDW 5QDX 5QDY 5QDZ 5QE0 5QE1 5QE2 5QE3 5QE4 5QE5 5QE6 5QE7 5QE8 5QE9 5QEA 5QEB 5QEC 5QED 5QEE 5QEF 5QEG 5QEH 5QEI 5QEJ 5QEK 5QEL 5QEM 5QEN 5QEO 5QEP 5QEQ 5QER 5QES 5QET 5QEU 5QEV 5QEW 5QEX 5QEY 5QEZ 5QF0 5QF1 5QF2 5QF3 5QF4 5QF5 5QF6 5QF7 5QF8 5QF9 5QFA 5QFB 5QFC 5QFD 5QFE 5QFF 5QFG 5QFH 5QFI 5QFJ 5QFK 5QFL 5QFM 5QFN 5QFO 5QFP 5QFQ 5QFR 5QFS 5QFT 5QFU 5QFV 5QFW 5QFX 5QFY 5QFZ 5QG0 5QG1 5QG2 5QG3 5QG4 5QG5 5QG6 5QG7 5QG8 5QG9 5QGA 5QGB 5QGC 5QGD 5QGE 5QGF 5T19 6B8E 6B8T 6B8X 6B8Z 6B90 6B95 6BAI 6CWU 6CWV 6NTP 6OL4 6OLQ 6OLV 6OMY 6PFW 6PG0 6PGT 6PHA 6PHS 6PM8	1JU5 2DVJ 2EYV 2EYW 2EYX 2EYY 2EYZ 2MS4 5UL6 6ATV
Enriched GO Terms of Interacting Partners?
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