NEB and ACO1

Data Source:
BioGRID (two hybrid, imaging technique)

		NEB	ACO1
Description		nebulin	aconitase 1
Image
GO Annotations	Cellular Component	Cytosol Actin Cytoskeleton Z Disc Extracellular Exosome	Cytoplasm Mitochondrion Endoplasmic Reticulum Golgi Apparatus Cytosol Extracellular Exosome
	Molecular Function	Protein Binding Structural Constituent Of Muscle Actin Filament Binding	RNA Binding Aconitate Hydratase Activity Protein Binding Iron-responsive Element Binding Metal Ion Binding Citrate Dehydratase Activity 3 Iron, 4 Sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Muscle Organ Development Somatic Muscle Development Muscle Filament Sliding Regulation Of Actin Filament Length Muscle Fiber Development Cardiac Muscle Thin Filament Assembly	Tricarboxylic Acid Cycle Citrate Metabolic Process Regulation Of Translation Cellular Iron Ion Homeostasis Post-embryonic Development Response To Iron(II) Ion Intestinal Absorption
Pathways		Striated Muscle Contraction	Iron uptake and transport
Drugs
Diseases		Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM) Nemaline myopathy
GWAS		Asparaginase-induced acute pancreatitis in acute lymphoblastic leukemia (onset time) ( 27114598) Creatine kinase levels ( 29403010) Estimated glomerular filtration rate ( 31152163 31451708) Letter-number span reordering ( 31596458) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Rapid automised naming of letters ( 30741946) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097) Squamous cell lung carcinoma ( 28604730)	Asthma ( 22561531) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Immune response to measles-mumps-rubella vaccine ( 24811271) Inflammatory skin disease ( 25574825) Lateral ventricle temporal horn volume ( 31530798) Motion sickness ( 25628336) Red blood cell count ( 32888494 27863252) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		24 interacting genes: ABI1 ACO1 ACTG2 ACTN4 AKTIP APC CALM1 DES ENO3 LIMS1 MTDH MYOM2 MYPN PTPN11 STRADB TMOD1 TMOD4 TPM1 TPM2 TRIM55 TRIM63 TTN XIRP1 XIRP2	7 interacting genes: APP CCDC69 CDC42 CLTC MYBPC1 NEB PXN
Entrez ID		4703	48
HPRD ID		01196	00013
Ensembl ID		ENSG00000183091	ENSG00000122729
Uniprot IDs		P20929 Q05C45 Q96MF8	P21399 Q9HBB2 V9HWB7
PDB IDs		1ARK 1NEB	2B3X 2B3Y
Enriched GO Terms of Interacting Partners?
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