NEB and ENO3

Data Source:
BioGRID (two hybrid)

		NEB	ENO3
Description		nebulin	enolase 3
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GO Annotations	Cellular Component	Cytosol Actin Cytoskeleton Z Disc Extracellular Exosome	Phosphopyruvate Hydratase Complex Extracellular Space Cytosol Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Protein Binding Structural Constituent Of Muscle Actin Filament Binding	Magnesium Ion Binding Phosphopyruvate Hydratase Activity Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Muscle Organ Development Somatic Muscle Development Muscle Filament Sliding Regulation Of Actin Filament Length Muscle Fiber Development Cardiac Muscle Thin Filament Assembly	Gluconeogenesis Glycolytic Process Aging Regulation Of Vacuole Fusion, Non-autophagic Response To Drug Skeletal Muscle Tissue Regeneration Canonical Glycolysis
Pathways		Striated Muscle Contraction	Glycolysis Gluconeogenesis
Drugs			2-phospho-D-glyceric acid Phosphoenolpyruvate 2-Phosphoglycolic Acid Phosphonoacetohydroxamic Acid
Diseases		Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM) Nemaline myopathy
GWAS		Asparaginase-induced acute pancreatitis in acute lymphoblastic leukemia (onset time) ( 27114598) Creatine kinase levels ( 29403010) Estimated glomerular filtration rate ( 31152163 31451708) Letter-number span reordering ( 31596458) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Rapid automised naming of letters ( 30741946) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097) Squamous cell lung carcinoma ( 28604730)	Red cell distribution width ( 32888494)
Interacting Genes		24 interacting genes: ABI1 ACO1 ACTG2 ACTN4 AKTIP APC CALM1 DES ENO3 LIMS1 MTDH MYOM2 MYPN PTPN11 STRADB TMOD1 TMOD4 TPM1 TPM2 TRIM55 TRIM63 TTN XIRP1 XIRP2	20 interacting genes: ALDOA APP DCTN1 DSP HSPB2 KALRN LINC01554 MAN2A2 MTMR14 NEB PGM1 PKM PNKD SGCG SNAPIN SPTB TCAP TRAPPC2 TRIM63 TTN
Entrez ID		4703	2027
HPRD ID		01196	11746
Ensembl ID		ENSG00000183091	ENSG00000108515
Uniprot IDs		P20929 Q05C45 Q96MF8	P13929
PDB IDs		1ARK 1NEB	2XSX
Enriched GO Terms of Interacting Partners?
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