HNRNPM and LYST

Data Source:
BioGRID (two hybrid)
HPRD (in vivo, two hybrid)

		HNRNPM	LYST
Description		heterogeneous nuclear ribonucleoprotein M	lysosomal trafficking regulator
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Nucleolus Cytoplasm Membrane Nuclear Matrix Paraspeckles Collagen-containing Extracellular Matrix Extracellular Exosome Catalytic Step 2 Spliceosome Post-mRNA Release Spliceosomal Complex Ribonucleoprotein Complex	Cytosol Microtubule Cytoskeleton Membrane
	Molecular Function	RNA Binding MRNA Binding Protein Binding Protein Domain Specific Binding	Protein Binding Protein Kinase Binding
	Biological Process	Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Fibroblast Growth Factor Receptor Signaling Pathway RNA Metabolic Process Regulation Of MRNA Stability Involved In Response To Oxidative Stress	Phagocytosis Lysosome Organization Protein Localization Protein Transport Leukocyte Chemotaxis Melanosome Organization Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Mast Cell Secretory Granule Organization Natural Killer Cell Mediated Cytotoxicity Defense Response To Bacterium Defense Response To Protozoan Pigmentation Defense Response To Virus
Pathways		FGFR2 alternative splicing mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA
Drugs
Diseases			Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS		Coronary artery disease ( 29212778)	Basophil percentage of white cells ( 32888494) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Post bronchodilator FEV1/FVC ratio ( 26634245) Systemic lupus erythematosus ( 26502338 19838195)
Interacting Genes		106 interacting genes: AKAP9 APC CDC5L CEACAM5 DUX4 ECPAS GMCL2 HGS HNRNPF HNRNPH1 JUN LENG8 LMO1 LMO2 LMO3 LYST MAGEA6 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I PLRG1 PRRC2A RBM4 RBM4B SMARCB1 STAT3 SUMO2 TCERG1 TEKT4 TRAF1 TSGA10 U2AF1 UBC UBE2I WDR77 YWHAG ZNF207	24 interacting genes: ATN1 CALM1 CELF4 CENPJ CNTROB CSNK2B DNAJC14 EFS ESRRA ESS2 HGS HNRNPM KPNB1 MED12 MRPL17 MRPS31 NCDN PCBP4 TNNI3 VTA1 YWHAB YWHAQ YWHAZ ZNF521
Entrez ID		4670	1130
HPRD ID		01188	06060
Ensembl ID		ENSG00000099783	ENSG00000143669
Uniprot IDs		P52272 Q59ES8	Q99698
PDB IDs		2DGV 2DH9 2DO0 2OT8
Enriched GO Terms of Interacting Partners?
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